Abstract

Metabolic diseases such as type 2 diabetes mellitus (T2DM) and metabolic syndromes (MetS) have been recognized as the important risk factors for asymptomatic intracranial vertebrobasilar stenosis (IVBS). Although fatty liver index (FLI) is significantly related with these diseases, the association between FLI and IVBS remains unclear. In the present study, 2368 participants (30–75 years) were recruited from a Chinese prospective cohort study of PMMJS. Amongst them, 2281 individuals who did not have IVBS at baseline were enrolled in the 6-year following-up study. In cross-sectional analysis based on the baseline characteristics, the results showed that FLI was positively related with IVBS prevalence. Compared to the participants with FLI < 30, the adjusted OR (95% CI) of IVBS was 2.07 (1.18, 3.62) and 2.85 (1.39, 5.18) in the groups of 30 ≤ FLI < 60 and FLI ≥ 60, respectively. In longitudinal analysis, the results showed that the participants with FLI ≥ 60 had an increased risk of asymptomatic IVBS compared to those with FLI < 30 [adjusted HR (95%CI): 1.65 (1.05, 2.60)]. Moreover, exclusion of persons with hypertension, T2DM and MetS did not alter the associations between FLI and asymptomatic IVBS. Therefore, our results suggest that elevated FLI is an independent risk factor for asymptomatic IVBS in Chinese adults.

Highlights

  • Vertebrobasilar system is comprised of the vertebral arteries and the basilar artery

  • We performed the sensitivity analysis to evaluate the cross-sectional associations between fatty liver index (FLI) and Intracranial vertebrobasilar stenosis (IVBS)

  • The results showed that exclusion of participants with hypertension, type 2 diabetes mellitus (T2DM) and metabolic syndromes (MetS) did not alter the association between FLI and prevalence of asymptomatic IVBS (OR FLI ! 30 vs FLI < 30: 2.44, 95% confidence intervals (CIs): 1.26–4.74) (Table 3)

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Summary

Introduction

Vertebrobasilar system is comprised of the vertebral arteries and the basilar artery. Each vertebral artery arises from a branch of the subclavian artery, and merges at the pontomedullary junction to form the basilar artery. Intracranial vertebrobasilar stenosis (IVBS) is a common cause of ischemic stroke and an important risk factor of stroke recurrence [1, 2]. Up to 20% of ischemic stroke is in the vertebrobasilar circulation territory [3, 4].

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