Abstract
BackgroundMany studies have reported associations between estrogen receptor (ER) gene polymorphisms and postmenopausal osteoporosis (PMOP) risk and bone mineral density (BMD), but the results are controversial. The aim of the present meta-analysis is to verify the association between ERα and ERβ gene polymorphisms and osteoporosis susceptibility and BMD in postmenopausal women.MethodsPubMed, EMBASE, Web of Science, the Cochrane Library and China WeiPu Library were searched. OR and WMD with 95% CI were calculated to assess the association.ResultsOverall, no significant association was observed between ERα XbaI, ERα PvuII and PMOP susceptibility in either overall, Caucasian or Asian populations. ERα G2014A was significantly associated with a decreased risk of PMOP in Caucasian populations. There was a significant association between ERβ RsaI and PMOP risk in both overall and Asian populations. Caucasian PMOP women with ERα XbaI XX and Xx genotypes had a higher LS Z value than women with xx genotype. ERα XbaI XX genotype was associated with increased FN BMD in overall and Caucasian populations, an increased FN Z value in Asians, and a decreased FN Z value in Caucasians. There was also a significant association between ERα XbaI Xx genotype and an increased FN Z value in either Asians or Caucasians. ERα PvuII PP genotype was associated with a low LS Z value in Caucasians and a low FN BMD and Z value in Asians. Pp genotype in PMOP women was significantly correlated with low LS BMD in overall populations, a low FN Z value in either overall, Caucasian or Asian populations.ConclusionEach ERα and ERβ gene polymorphism might have different impact on PMOP risk and BMD in various ethnicities.
Highlights
Many studies have reported associations between estrogen receptor (ER) gene polymorphisms and postmenopausal osteoporosis (PMOP) risk and bone mineral density (BMD), but the results are controversial
ERα PvuII and femoral neck bone mineral density (BMD g/ cm2 and BMD Z value) We further found that the ERα PvuII PP genotype was associated with decreased femoral neck BMD and Z value compared with the pp. genotype in Asians, while no significant difference in femoral neck BMD and Z value was observed in either overall and Caucasian populations (Table 5)
ERα XbaI might not play a key role in attainment and maintenance of peek bone mass in postmenopausal women [24], and it could be understood why no significant association was observed between ERα XbaI and lumbar spine BMD
Summary
Many studies have reported associations between estrogen receptor (ER) gene polymorphisms and postmenopausal osteoporosis (PMOP) risk and bone mineral density (BMD), but the results are controversial. Postmenopausal osteoporosis (PMOP) is a common metabolic bone disorder characterized by low bone mineral density (BMD) and increased fracture risks [1,2,3]. Genetic factors including genes and gene polymorphisms may play an important role in the development of PMOP [9]. Estrogen is another important hormone that plays an important role in the pathogenesis of PMOP, knowing that reduced ovarian production of estrogen after menopause is a cause for the initial phase of rapid bone loss and osteoporosis in women [3]. The results of studies currently available about this issue are controversial
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