Abstract

It is known that a variety of bio-psycho-social factors are important in determining disease prevalence. In this paper we look at psychiatric diagnoses and how these are influenced by gender differences, geographical differences, urbanity and exposure to trauma, namely childhood physical and sexual abuse. Data was collected prospectively over a fifty two week period across 6 research sites in Ireland. Multiple diagnostic and psycho-social interview schedules were utilized for eligible patients. Statistical tests of association between diagnoses and biopsychosocial variables were conducted. A total of five hundred and forty participants were included in this study. Depression was the most common diagnosis in both sexes. Depression was significantly more common in females and alcohol dependence significantly more common in males. Depression, anxiety and schizophrenia were all more common in the North of Ireland with rates of bipolar affective disorder and alcohol dependence similar between the North and South. Depression and anxiety affected largely equal numbers in urban and rural areas but schizophrenia, bipolar affective disorder and alcohol dependence were more common in rural areas. 28% of the study population experienced child sexual abuse and 20% child physical abuse. Both forms of abuse were more common in females and in the North of Ireland. Urban areas revealed higher levels of childhood sexual abuse. Depression was the most common diagnosis in those with a history of sexual abuse and schizophrenia most common in those with a history of physical abuse. The differing rates of diagnoses between the North and South may reflect historical background differences. Our analysis reveals a high level of both childhood sexual and physical abuse in the study population. Both forms of abuse were more common in the North and this is associated with higher rates of schizophrenia. Our study supports trauma as a risk factor for depression and schizophrenia.

Highlights

  • The prevalence of psychiatric disorders is influenced by a large number of biological, psychological and social factors.Of the various biological factors, gender differences are evident within certain psychiatric disorders.Depression is twice as common in women and alcohol dependence more than twice as common in men [1]

  • There have been reports suggesting a link between childhood physical abuse and psychosis [5,6]

  • To the best of our knowledge this is the first study looking at common psychiatric diagnoses and their associations with gender, site, region and trauma on the island of Ireland

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Summary

Introduction

The prevalence of psychiatric disorders is influenced by a large number of biological, psychological and social factors.Of the various biological factors, gender differences are evident within certain psychiatric disorders.Depression is twice as common in women and alcohol dependence more than twice as common in men [1]. Rates of schizophrenia and bipolar affective disorder are similar between the sexes [1]. With regard to social factors, psychiatric disorders are correlated with urbanisation [2]. A recent meta-analysis investigating geographical differences for common psychiatric diagnoses found higher rates for mood and anxiety disorders in urban areas with no difference found for substance misuse [3]. The association between childhood sexual abuse and psychosis has been a topic of interest in recent times. It is considered that the association between childhood sexual abuse and psychosis is large, and may be causal [4,5,6,7]. There have been reports suggesting a link between childhood physical abuse and psychosis [5,6]

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