Abstract
BackgroundPulmonary hypertension (PH) is a common complication of chronic respiratory disease. Recent studies have reported diabetes mellitus (DM) to be a poor prognostic factor in patients with chronic respiratory disease, including chronic obstructive pulmonary disease or interstitial pneumoniae. However, the association between DM and PH in chronic respiratory disease remains unclear. In this study, we aimed to investigate whether DM is a predictor of PH in patients with chronic respiratory disease.MethodsWe prospectively analyzed 386 patients in our hospital with chronic respiratory disease. An echocardiographic pressure gradient between the right atrium and the right ventricle of ≥ 40 mmHg was defined as PH. We compared the clinical characteristics and impact of DM between chronic respiratory disease patients with and those without PH.ResultsOf the 386 patients, 42 (10.9%) were diagnosed as having PH. The PH group had higher modified medical research council (mMRC) grade and complication rate of DM, but not hypertension and hyperlipidemia, when compared to the non-PH group. Multivariable logistic regression analysis revealed that mMRC scale (odds ratio 1.702, 95% confidence interval, 1.297 to 2.232, P < 0.001) and presence of DM (odd ratio 2.935, 95% confidence interval, 1.505 to 5.725, P = 0.002) were associated with PH in chronic respiratory disease patients.ConclusionDM is potentially associated with PH and is an independent factor for prediction of PH in patients with chronic respiratory disease.
Highlights
Pulmonary hypertension (PH) due to chronic respiratory disease, such as chronic obstructive pulmonary disease (COPD) and/or interstitial pneumonia, is classified as group 3 PH by the World Health Organization and has been reported to be a common form of PH cases [1].Various degrees of PH occur in severe respiratory disease
Multivariable logistic regression analysis revealed that modified medical research council (mMRC) scale and presence of diabetes mellitus (DM) were associated with PH in chronic respiratory disease patients
DM is potentially associated with PH and is an independent factor for prediction of PH in patients with chronic respiratory disease
Summary
Pulmonary hypertension (PH) due to chronic respiratory disease, such as chronic obstructive pulmonary disease (COPD) and/or interstitial pneumonia, is classified as group 3 PH by the World Health Organization and has been reported to be a common form of PH cases [1].Various degrees of PH occur in severe respiratory disease. Pulmonary hypertension (PH) due to chronic respiratory disease, such as chronic obstructive pulmonary disease (COPD) and/or interstitial pneumonia, is classified as group 3 PH by the World Health Organization and has been reported to be a common form of PH cases [1]. Right heart catheterization (RHC), which is essential for a definite diagnosis of PH (defined as mean pulmonary arterial pressure > 20 mmHg and pulmonary vascular resistance (PVR) ! Pulmonary hypertension (PH) is a common complication of chronic respiratory disease. Recent studies have reported diabetes mellitus (DM) to be a poor prognostic factor in patients with chronic respiratory disease, including chronic obstructive pulmonary disease or interstitial pneumoniae. We aimed to investigate whether DM is a predictor of PH in patients with chronic respiratory disease
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