ASSOCIATIONS BETWEEN BIOMARKERS AND SYMPTOMS IN PATIENTS WITH COMPLAINTS SUSPECTED TO BE EARLY HIP OSTEOARTHRITIS. A CHECK STUDY

Abstract

Purpose: Frequent and debilitating symptoms of hip osteoarthritis are pain while walking, fatigue and nocturnal pain. The aim of the present study was to assess associations of five biochemical markers of joint tissue turnover and inflammation (hs-CRP, CTX-II, COMP, PINP and OC) with the presence and 2-year progression of pain while walking, fatigue and nocturnal pain. CTX-II and COMP are markers of cartilage and bone metabolism. CRP is a nonspecific marker of inflammation. PINP (aminoterminal propeptide of type I procollagen) and OC (osteocalcin) are bone synthesis markers.