Abstract

Atopic dermatitis is a heterogeneous, chronic, and inflammatory skin disease that is associated with a profound symptom burden. Recent studies have demonstrated associations between atopic dermatitis and a number of multi-organ and systemic disorders. The origin of these comorbid conditions is likely multifactorial, with combined effects of skin-barrier disruption, immune dysregulation, intense symptoms, and iatrogenic complications. Some of these comorbid conditions appear to be related to the underlying severity of atopic dermatitis and inadequate disease control. This review will summarize recent developments in the understanding of the comorbid health disorders associated with atopic dermatitis, particularly infections, sleep disturbances, and cardiovascular disease.

Highlights

  • Atopic dermatitis (AD) is a chronic inflammatory skin disease that is associated with a heterogeneous and often variable constellation of symptoms and signs

  • We found that moderate-to-severe AD was associated with central obesity, as judged by elevated body mass index (BMI), waist circumference ≥85th percentile, and waist-to-height ratio of ≥0.5

  • We found that AD was associated with significantly increased odds of cardiovascular risk and disease, similar to that observed in psoriasis, hidradenitis, pemphigus, and pemphigoid[71]

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Summary

12 Mar 2018

F1000 Faculty Reviews are written by members of the prestigious F1000 Faculty. They are commissioned and are peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. Any comments on the article can be found at the end of the article

Introduction
Methods
Conclusions
10. Silverberg JI: Association between childhood eczema and headaches
13. Silverberg JI
17. Silverberg JI
Findings
61. Silverberg JI
Full Text
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