Abstract
BackgroundThere is no evidence whether it is best to stop drinking alcohol at all or whether it is okay to drink a little in that light-to-moderate alcohol use was associated with low cardiovascular disease (CVD) compared to non-drinker among colorectal cancer (CRC) survivors, who are regarded as vulnerable to CVD. Therefore, we evaluated the association between alcohol consumption and incident CVD among long-term survivors of CRC.MethodsThis population-based, retrospective cohort study utilized data from the Korean National Insurance Service of 20,653 long-term survivors of CRC diagnosed between 2006 and 2012. Participants were followed up to the date of CVD, death, or December 31, 2018. All patients were categorized according to their daily alcohol consumption (g/day). The outcomes were incident CVD, including ischemic heart disease (IHD) and ischemic and hemorrhagic stroke, analyzed using the Cox proportional hazards regression after adjusting for cardiovascular risk factors and history of chemotherapy and radiotherapy.ResultsThere was no association between alcohol consumption and incident CVD among long-term survivors of CRC. Additionally, hazardous alcohol consumption (≥ 40 g/day in male patients and ≥ 20 g/day in female patients) was associated with increased CVD, ischemic stroke, and hemorrhagic stroke (adjusted hazard ratio [95% confidence interval]: 1.51 [1.15–1.97], 1.60 [1.03–2.48], and 2.65 [1.25–5.62], respectively) compared with non-drinkers.ConclusionNo discernable protective association was found between alcohol consumption and incident CVD for even light-to-moderate drinking among long-term survivors of CRC. Alcohol consumption ≥40 g/day in male patients and ≥ 20 g/day in female patients was associated with an increased risk of stroke compared with non-drinkers. These novel results provide useful evidence when advising survivors of CRC regarding alcohol use.
Highlights
There is no evidence whether it is best to stop drinking alcohol at all or whether it is okay to drink a little in that light-to-moderate alcohol use was associated with low cardiovascular disease (CVD) compared to nondrinker among colorectal cancer (CRC) survivors, who are regarded as vulnerable to CVD
Alcohol consumption of ≥40 g/day in male patients and ≥ 20 g/day in female patients was associated with increased CVD compared with the non-drinking group after adjusting for the variables described above, whereas the lowest risks were found in the 10–19.9 g/ day group for male patients and the < 5 g/day group for female patients
The quantitative values for the adjusted hazard ratio (HR) for CVD, ischemic heart disease (IHD), and stroke for male and female participants are presented in Tables 2 and 3, respectively
Summary
There is no evidence whether it is best to stop drinking alcohol at all or whether it is okay to drink a little in that light-to-moderate alcohol use was associated with low cardiovascular disease (CVD) compared to nondrinker among colorectal cancer (CRC) survivors, who are regarded as vulnerable to CVD. 5 years after diagnosis and treatment of CRC, patients are informed of 5-year survival and recommended self-management with community care For this reason, the lifestyle of long-term CRC survivors tends to return to the initial state before diagnosis, alcohol habit. There is no evidence whether it is best to stop drinking alcohol at all or whether it is okay to drink a little in that light-to-moderate alcohol use was associated with low ischemic heart disease (IHD) and stroke mortality compared to non-drinker [5]. We investigated the association between alcohol use and CVD among long-term survivors of CRC
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