Abstract
ObjectivesThe previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, in European populations. This study aims to assess the genetic association of the variant rs75932628-T with PD and leucoaraiosis (LA) in a Han Chinese population.SettingThis population-based study was conducted in China by Xiamen University and its affiliated hospital.Participants308 patients with LA, 342 patients with PD and 198 healthy blood donors were recruited from the First Affiliated Hospital of Xiamen University.Outcome measuresGenotyping was performed by molecular beacon real-time PCR and Sanger sequencing.ResultsNone of our participants carried the rs75932628-T mutation.ConclusionsOur results corroborate and extend previous findings, concluding that the variant rs75932628-T (p.R47H) in TREM2 is not a risk factor for LA or PD in the Han Chinese population.
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