Association study of schizophrenia and synaptosomal-associated protein 25kDa gene polymorphism

Abstract

Objective To investigate the relationship between single nucleotide polymorphism(rs8636)in synaptosomal-associated protein 25kDa gene(SNAP-25)and schizophrenia.Methods The genotypes and alleles in 300 patients with schizophrenia and 300 normal controls were examined with polymerase chain reaction and restriction fragment length polymorphism technique.Analyzed the association between schizophrenia and polymorphism of SNAP-25 gene.Results ①There was no deviation from Hardy-Weinberg disequilibrium for the frequency distribution of genotypes and alleles in the two groups(X~2=2.69，v=1，P＞0.05；X~2=2.52，v=1，P＞0.05).②There were significant differences in the frequencies of the genotypes and alleles between patients andcontrols(X~2=6.454，P＜0.05；X~2=7.033，P＜0.05).③The frequency of C/C genotype(65.0%)and C alleles (79.7%)in patients were higher than that in the controls(X~2=5.848，P＜0.05；OR=1.50).The frequency of T/T genotype(5.7%)in patients was lower than that in the controls(X~2=2.453，P＞0.05).Conclusion There is a relationship between rs8636 in SNAP-25 gene and schizophrenia.The genotype C/C and alleles C may be a risk factor to the pathogenesis of schizophrenia. Key words: Schizophrenia; Synaptosomal-associated protein 25; Gene; Case-control study