Abstract
This study examined whether a functional polymorphism (A118G) in the gene encoding the mu-opioid receptor protein, which causes an Asn40Asp substitution in the receptor's extracellular domain, is associated with personality factors, as defined by the Five-Factor Model of Personality. Healthy subjects (n=446) and substance-dependent subjects (n=335) underwent a diagnostic interview, completed the NEO Five-Factor Inventory and provided a blood sample for genotyping. Controlling for demographic features and substance dependence diagnosis, analyses examined the allelic association of Asn40Asp with the five personality dimensions. There was no evidence for allelic association with any of the five personality dimensions. These findings fail to support the hypothesis that Asn40Asp alleles moderate the development of personality dimensions, as measured by the Five-Factor Model.
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