Abstract
HLA and childhood acute lymphoblastic leukemia (cALL) association has been reported by a number of studies and amongst varied populations. However the same has not yet been reported in Indian population. We undertook a study to analyze the Human Leukocyte Antigen (HLA) Class I (-A, -B, -C) and HLA class II (-DRB1, -DQB1) frequency in Indian cALL patients. The study included 84 cALL patients and 206 healthy individuals as control population. The samples were HLA typed using PCR-sequence-specific oligonucleotide probes technique. We found significant positive associations at HLA-A*33 (23.80% vs. 8.25%, P = 0.0044) and HLA-DRB1*12 (9.52% vs. 0.97%, P = 0.014) with cALL when compared to control. The gender specific association revealed the significance in both the genders. However the higher frequency was observed in female patients for both the alleles. The age-specific association revealed that HLA-A*33 was significant in both the age groups (<10 years and >10 years). In addition, the homozygosity of HLA-DR*07 was seen in cALL patients. The present study can be used as a baseline study for future studies and the results can be verified in many more such studies.
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