Abstract
BackgroundPrevious genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese population has found that SNPs in LPP gene were nominally significant in PCOS patients (P around 10E-05). Replication of the GWAS was applied to further confirm the relationship between LPP gene and PCOS.MethodsThree polymorphisms of LPP gene (rs715790, rs4449306, rs6782041) were selected and replicated in additional 1132 PCOS cases and 1142 controls. Genotyping of LPP gene was carried out by Taqman-MGB method.ResultsIn rs715790, the allele frequency is significantly different between the PCOS group and the control group. Meta-analysis showed that the allele frequencies of the three SNPs rs715790 (Pmeta = 1.89E-05, OR = 1.23), rs4449306 (Pmeta = 3.0E-04, OR = 1.10), rs6782041 (Pmeta = 2.0E-04, OR = 1.09), were significantly different between PCOS cases and controls.ConclusionsOur results suggest that LPP gene might be a novel candidate for PCOS.
Highlights
Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder affecting 6–8% reproductive-aged women [1]
Women with polycystic ovary syndrome (PCOS) have a high risk suffering from metabolic syndrome [3], type 2 diabetes (T2D) and cardiovascular diseases [4,5]
Subjects The 1132 PCOS cases and 1142 controls were of Han Chinese population, recruiting from the Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University from June 2009 to May 2011
Summary
Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder affecting 6–8% reproductive-aged women [1]. It is a heterogeneous disease characterized by oligoovulation and/or anovulation, clinical and/or biochemical hyperandrogenism and polycystic ovaries on ultrasound [2]. We conducted a genome-wide association study (GWAS) on PCOS in Han Chinese, including single nucleotide polymorphisms (SNPs) with P value less than 10E-06 were replicated, in which three susceptibility loci were confirmed [8]. Previous genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese population has found that SNPs in LPP gene were nominally significant in PCOS patients (P around 10E-05). Replication of the GWAS was applied to further confirm the relationship between LPP gene and PCOS
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