Association study of clusterin polymorphism rs11136000 with late-onset Alzheimer's disease in Bai population

Abstract

Objective To explore the association between clusterin(CLU) gene rs11136000 polymorphism and late-onset Alzheimer's disease (LOAD) in Bai population from Dali Bai Autonomous Prefecture of Yunnan Province. Methods A case-control study including 109 LOAD patients and 120 normal controls matched for age, sex and level of education was taken in Dali Bai population. Polymerase chain reaction(PCR) and single nucleotide polymorphism (SNP) site testing were used to detect genotype and allele frequency of CLU SNP rs11136000.SPSS 17.0 was applied to analyze the data. Result ①The different frequency (C: 65.60%, T: 34.40%, CC: 38.53%, CT: 54.13%, TT: 7.34%) of CLU SNP rs11136000 genotypes and alleles distribution in Bai between LOAD patients and healthy controls showed no statistical significance(χ2=1.529, P=0.216; χ2=2.805, P=0.246). ②The serum total cholesterol (TC) of LOAD patients was significantly higher than that in that of control group(t=2.508, P=0.013). Conclusion The results suggest that CLU rs11136000 polymorphism may not be the susceptible gene of LOAD, and high serum total cholesterol is more common in LOAD patients. Key words: Late-onset Alzheimer's disease; Clusterin gene; Polymorphism; Bai population