Abstract
BackgroundModulation of the immune system is one of the principal roles of Vitamin D, for which the effects are exerted via the vitamin D receptor (VDR). Importantly, variants in the VDR gene have been susceptible in the past to raise the risk of asthma in several populations. These effects of VDR allelic markers remain speculative in the Chinese Han population.ResultsA case-control study of 1090 individuals including 567 asthmatic patients was realized on five SNPs within the VDR gene. Only rs7975232 (ApaI) marker showed a significant association with asthma (P = 0.009). Haplotype analysis of the five VDR polymorphisms showed a significant association with asthma (global-p value = 0.012).ConclusionAlthough the susceptibility of VDR gene variants with asthma could not be confirmed for all SNPs tested in this study, the significant association obtained for rs7975232 provides evidence for a previously unknown report about the Chinese Han population and may raise the susceptibility of VDR to be a candidate gene for asthma.
Highlights
Modulation of the immune system is one of the principal roles of Vitamin D, for which the effects are exerted via the vitamin D receptor (VDR)
Our results demonstrated that VDR rs7975232 (ApaI) variant was associated with asthma susceptibility in the cohort studied
For the five polymorphisms tested in this study within the VDR gene sequence, genotype distributions were in Hardy-Weinberg equilibrium in both patients and controls
Summary
Modulation of the immune system is one of the principal roles of Vitamin D, for which the effects are exerted via the vitamin D receptor (VDR). Recent discoveries made in the field of molecular biology have reported that vitamin D derived from diet and supplements is not a vitamin, but a steroid with immunosuppressive properties when elevated [1]. It has been linked with lessening symptoms of autoimmune diseases like multiple sclerosis [2], Crohn's disease [3], and rheumatoid arthritis [4]. The interaction of 1, 25(OH)2D3 with VDR and its cofactors modulates many biological activities of the neural, immune, and endocrine systems; including calcium and phosphorous homeosta-
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