Abstract
Objectives : Tardive dyskinesia (TD) is a serious and sometimes irreversible adverse effect that may develop during long-term antipsychotics treatment. Previous studies have suggested that brain serotonergic systems are related to TD vulnerability and tryptophan hydroxylase (TPH) is the rate limiting enzyme in the biosynthesis of serotonin. This study aimed to investigate the association between TPH2 gene -703G/T polymorphism (rs4570625) and antipsychotic-induced TD in the Korean schizophre- nia patients. Methods : We investigated whether TPH2 gene -703G/T polymorphism is associated with antipsychotic-induced TD in 280 Ko- rean schizophrenia patients. The subjects with TD (n=105) and without TD (n=175) were matched for antipsychotic drug expo- sure and other relevant variables. Results : There was no significant difference in the distribution of genotypic (χ 2 =3.00, p=0.223) and allelic (χ 2 =0.19, p=0.661) frequencies between patients group with TD and without TD. There was no significant difference in total Abnormal Involuntary Movement Scale score (F=1.95, p=0.362) among the genotype groups, either. Conclusions : The present study does not support that TPH2 gene -703G/T polymorphism is involved in TD of the Korean schizophrenia subjects. (Korean J Schizophr Res 2012;15:34-38)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
