Abstract
To investigate the association between the APM1 SNP rs 13061862 and type 2 diabetes mellitus (T2DM), a total of 603 Han subjects from Hubei Province were genotyped for the APM1 SNP T45G. Both family-based case- control and unrelated case-control designs were used. The frequencies of the G allele and GG genotype for T2DM patients were significantly higher than those for controls (G: 42.0% vs. 21.7%, P<0.001; GG: 13.6% vs. 4.5%, P= 0.032) in all subjects. The GG genotype was associated with higher risk of T2DM in family-based case-control groups (GG: 17.8% vs. 5.6%, P = 0.011), while the G allele and GG genotype for T2DM patients were significantly higher than those for controls in the unrelated case-control groups (GG: 12.2% vs. 3.9%, P = 0.025). Logistic regression analysis suggested that GG genotype was the genetic risk factors for T2DM (OR = 3.58, 95% CI = 1.70-7.54). In conclusion, the APM1 SNP T45G is associated with T2DM risk, and the GG genotype may be a genetic risk factor of T2DM in Han population of Hubei Province.
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