Abstract
The aim of this study is to assess the association of two polymorphisms, the cartilage intermediate layer protein 2 (CILP2) G/T and angiotensin converting enzyme (ACE) I/D, with blood pressure and anthropometrical and biochemical parameters related to the development of cardiovascular disease. The entire study sample comprised 341 women ranging in age from 39 to 65 years. The CILP2 genotypes were determined by PCR-RFLP and the ACE genotypes by PCR. The Bonferroni pairwise comparisons showed the effect of the CILP2 genotype on high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), apoB-to-apoA1 ratio, the total cholesterol (TC)-to-HDL-C ratio, non-HDL-C, and the LDL-C-to-HDL-C ratio (P < 0.05). Here, higher mean levels of HDL-C and lower mean levels of the remaining above mentioned lipid parameters were registered in the GT/TT genotype carriers than in GG carriers. Statistically significant association was identified between the ACE genotype and the following parameters: TC, LDL-C, and non-HDL-C (P < 0.05). The II genotype can lower serum level of TC (B = 0.40), LDL-C (B = 0.37), and non-HDL-C levels. The results of this study suggest that the minor T allele of CILP2 gene and I allele of ACE gene have a protective effect against elevated serum lipid and lipoprotein levels.
Highlights
Increased blood lipid and lipoprotein levels, low HDL cholesterol concentration, glucose intolerance, hypertension, and obesity have emerged as some of the most serious public health concerns in recent decades
Kathiresan et al [1] reported that an intergenic region between cartilage intermediate layer protein 2 (CILP2) and PBX4 located in chromosome 19p13 is associated with concentrations of lowdensity lipoprotein cholesterol (LDL-C) and triglycerides (TG)
The aim of this study is to examine if genetic variants in both CILP2 and angiotensin converting enzyme (ACE) genes are associated with different anthropometrical, biochemical parameters and blood pressure in a nonclinical study sample of midlife women from Slovakia, including both premenopausal and postmenopausal subjects
Summary
Increased blood lipid and lipoprotein levels, low HDL cholesterol concentration, glucose intolerance, hypertension, and obesity have emerged as some of the most serious public health concerns in recent decades. These variables are closely related to a number of pathological disorders including cardiovascular disease (CVD). Recent increases in CVD risk factors often reflect lifestyle changes, genetic factors play a substantial role. Genome-wide association studies have revealed the association of DNA polymorphisms in both the CILP2 gene (cartilage intermediate layer protein) and the ACE gene (angiotensin converting enzyme) with CVD risk factors [1,2,3]. Genetic analysis has highlighted a significant association between polymorphisms in the CILP gene and osteoarthritis progression [6]
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