Abstract
Xanthelasma palpebrarum (XP) is the most common cutaneous xanthoma occurs over or surrounding the eyelids in yellowish color and various shapes. The objective of this study was to describe the status of cardiovascular disease risk factors in XP patients and determine their association with XP. A case-control study was conducted among 81 cases (have XP) and 81 controls (no XP) among patients attended for cardiac check-up between January 2019 to July 2019 at Ad-Din Women's Medical College Hospital, Dhaka, Bangladesh. Among 162 subjects were interviewed in our study, majority were female (62.3%). XP were found more prevalent among female and several cardiac risk factors were significantly associated with XP. The chi-square analysis indicates gender (p=0.035), BMI (p=0.01), Angina history (p=0.008), and serum LDL (p=0.024) were significantly associated with presence of XP. A higher percentage of patients with high total serum cholesterol, TG levels, and LDL was observed in patients with XP in compared to control group. Our study reveals an increased presence of cardiovascular disease risk factors among patients with xanthelasma. Moreover, a statistically significant association of gender, BMI, angina history, and serum LDL with XP were observed.
 Asian J. Med. Biol. Res. June 2019, 5(4): 324-329
Highlights
Xanthelasma palpebrarum (XP) is a Xanthoma appeared as soft, velvety, yellowish papules and plaques of bilateral, symmetrical shaped over the eyelids (Akyüz et al, 2016; Oosterveer et al, 2009)
Our case-control study was sought to find out the association between Xanthelasma palpebrarum (XP) and cardiac risk factors
A validated questionnaire was used to collect information from the respondents. The both age and Body mass index (BMI) were found higher among participants with XP in compared to participants without XP
Summary
Xanthelasma palpebrarum (XP) is a Xanthoma appeared as soft, velvety, yellowish papules and plaques of bilateral, symmetrical shaped over the eyelids (Akyüz et al, 2016; Oosterveer et al, 2009). Xanthelasma palpebrarum (XP) is the most recurrently seen cutaneous xanthoma. They are problematic as they have a common tendency of becoming larger, and become permanent (Jain et al, 2007; Özdöl et al, 2008; Pandhi et al, 2012). Though the reason of xanthelasma development remains ambiguous, lipid abnormalities are deliberated as one of the predisposing factors (Wang et al, 2018). The foamy histiocytes consist of cholesterol crystals and non-membrane bound lipid vacuoles (Pandhi et al, 2012; Wang et al, 2018). A number of previously conducted research identified increased biochemical lipid profiles for
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
