Abstract
Aging is accompanied by various functional modifications determined by their environment, lifestyle, nutrition, and genetics. Based on these factors, it is essential to verify the vitamin deficiency in the elderly population. Hypovitaminosis D is commonly present in human aging, increasing the chances of developing noncommunicable chronic diseases. The VDR gene TaqI polymorphism may modify the vitamin D metabolic pathway by altering the interaction between the vitamin D receptor and the active circulating vitamin D. Therefore, this study aimed to investigate the association between serum vitamin D and biochemical and genetic factors, considering the TaqI polymorphism of the VDR gene, in an elderly population of the Federal District. The study was a descriptive, case-control, quantitative, and cross-sectional type and was conducted in two basic health units in the administrative region of Ceilândia, Federal District, DF, Brazil, with women aged 60 years or older. Anthropometric, biochemical, and genetic parameters (VDR TaqI polymorphism) were evaluated. The adopted significance level was 5%, and statistical analyses were performed using the SPSS version 20.0 program. The study consisted of 128 participants. The most prevalent age was from 60 to 65 years (N = 53; 41.4%). 66 elderly (51.6%) were part of the case group (hypovitaminosis D), while 62 were in the control group. In the case group, 30.2% had grade I obesity, 77.3% were hypertensive, and 51.5% were diabetic. The TT genotype was present in 47% of the case group and 54.8% in the control group (p=0.667). There was no association between serum vitamin D levels and the VDR gene variant TaqI polymorphism in an elderly Brazilian population.
Highlights
IntroductionPopulation aging is a growing transformation in Brazil
Population aging is a growing transformation in Brazil. is demographic transition may be elucidated by changes in the mortality and the birth rates, as well as the populations’ nutritional, economic, social, and disease profiles [1, 2].According to the Brazilian Institute of Geography and Statistics (IBGE), there will be about 7 million more women than men by 2050 in Brazil, and the elderly will probably be represented by 76 older men per 100 older women [3].Aging happens with increasing age, emerging structural, and functional changes in the body. e observed physiological changes increase over the years being discreet and natural
Us, this study aims to investigate the association between serum vitamin D and biochemical and genetic factors, considering the TaqI polymorphism of the VDR gene in an elderly population of the Federal District
Summary
Population aging is a growing transformation in Brazil. Is demographic transition may be elucidated (inferred) by changes in the mortality and the birth rates, as well as the populations’ nutritional, economic, social, and disease profiles [1, 2]. According to the Brazilian Institute of Geography and Statistics (IBGE), there will be about 7 million more women than men by 2050 in Brazil, and the elderly will probably be represented by 76 older men per 100 older women [3]. E observed physiological changes increase over the years being discreet and natural. Aging happens with increasing age, emerging structural, and functional changes in the body. Such changes can lead to loss of function or disease. Biological changes may develop in various ways depending on the individual’s genetics and lifestyle, influenced by psychological, cultural, and social aspects [4,5,6].
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