Abstract
BackgroundVitamin D (Vit D) function in asthma progression has been studied well. The effects of genetic variations in Vit D pathway molecules have been also studied, although the results are contradicted. In the present study, for the first time we examined the Vit D pathway molecules included serum Vit D and vitamin D‐binding protein (VDBP) and also genetic variations in the vitamin D receptor (VDR) and VDBP in a Kurdish population with asthma.MethodsAn enzyme‐linked immunosorbent assay (ELISA) method was used to measure the serum Vit D and VDBP. VDR rs1544410 and rs2228570 and VDBP rs7041 were assessed by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP).ResultsThe serum level of Vit D significantly decreased in asthmatic patients versus controls (16.26 ± 6.76 vs 23.05 ± 10.57 ng/mL, P value = .001). We observed an indirect correlation between Vit D and clinical findings. We also found an increased level of serum VDBP in patients as compared to the controls (1044.6 ± 310.82 vs 545.95 ± 121.73 µg/mL, P value < .0001). Besides, the risk of asthma progression was increased in patients with the VDR rs2228570 CC and VDBP rs7041 GG genotypes (OR = 3.56, P = .0382 and OR = 2.58, P = .01, respectively).ConclusionIn summary, our results explain the influence of the genetic variations in VDR and VDBP in addition to Vit D and VDBP serum concentrations on asthma susceptibility in the Kurdish population.
Highlights
Asthma is a chronic inflammation of lungs that characterized by ob‐ struction and hyper‐responsiveness of airways and causes clinical symptoms including shortness of breath, chest tightness or pain, and coughing during night or early in the morning.[1]
Our previous study clearly revealed that alteration in Vitamin D (Vit D) metabolism including decline serum Vit D concentration, genetic variations in vitamin D receptor (VDR) and vitamin D‐binding protein (VDBP) genes, and higher levels of serum VDBP increases the risk of chronic urticaria.[22]
Decline in Vit D levels linked to clini‐ cal findings included FEV1%, forced vital capacity (FVC), FEV/FVC, and asthma severity, while increased levels of the serum VDBP did not link with those characteristics
Summary
Asthma is a chronic inflammation of lungs that characterized by ob‐ struction and hyper‐responsiveness of airways and causes clinical symptoms including shortness of breath, chest tightness or pain, and coughing during night or early in the morning.[1]. The role of rs7041 SNP on progres‐ sion of some respiratory diseases has been previously studied 19; there is a paucity of evidence with regard to the relation of those polymorphism with the development of asthma.[19,20,21] As it was mentioned, the potential involvement of VDR in the progression of asthma has been previously investigated, the results are controversy. Our previous study clearly revealed that alteration in Vit D metabolism including decline serum Vit D concentration, genetic variations in VDR and VDBP genes, and higher levels of serum VDBP increases the risk of chronic urticaria.[22] the current study was conducted to evaluate the possible association between VDR BsmI, FokI, VDBP HaeIII SNPs, and Vit D and VDBP concentrations with asthma susceptibility in a Kurdish population
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