Abstract
Several studies have found an association between vitamin D deficiency and age-related macular degeneration (AMD).1-4 Vitamin D has been shown to have immunomodulatory and antiangiogenic properties, suggesting a biologically plausible role in the pathogenesis of AMD.5 This study examines the possible association of vitamin D deficiency and subsequent incidence of first diagnosis of nonneovascular and neovascular AMD in a cohort of Medicare beneficiaries. To our knowledge, this is the first study to evaluate incidence rather than prevalence of AMD in a large sample of vitamin D–deficient patients.
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