Abstract
Objectives: The aim of the study was to assess the association between visceral and subcutaneous fat with glucose intolerance, adipocytokines, inflammatory markers and carotid IMT in Asian Indians. Design and methods: Subjects with NGT ( n = 85), IGT ( n = 49) and T2DM ( n = 93) were randomly selected from CURES. Total abdominal, visceral and subcutaneous fat were measured using Helical CT scan. Adiponectin, hs-CRP, TNF-alpha, oxidized LDL, visfatin and leptin and IMT and insulin resistance were assessed. Results: Total abdominal fat ( p = 0.041) and the visceral fat ( p = 0.039) but not subcutaneous fat progressively increased from NGT, IGT and T2DM subjects. With increasing quartiles of visceral fat, there was a significant increase in insulin resistance ( p = 0.040); significant decrease in adiponectin ( p = 0.043) and increase in TNF-alpha ( p = 0.028), hs-CRP ( p = 0.043), OX-LDL ( p = 0.034) and visfatin ( p = 0.040), and carotid IMT ( p = 0.047) was observed. Conclusion: Visceral fat levels increased with increasing glucose intolerance and are associated with decreased levels of adiponectin and increased levels of hs-CRP, TNF-alpha, oxidized LDL, visfatin, HOMA-IR and IMT.
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