Association of VEGF and VDR gene- gene and gene- smoking interaction on risk of multiple myeloma in Chinese Han population.

Peng Chen,Jin-Xing Lou,Hui-Ren Chen,Zhi Guo,Xue-Peng He,Bing Liu,Yuan Zhang,Zhen-Lan Du

doi:10.18632/oncotarget.16510

Peng Chen, Jin-Xing Lou + Show 6 more

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https://doi.org/10.18632/oncotarget.16510

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Journal: Oncotarget	Publication Date: Mar 23, 2017
Citations: 8	License type: CC BY 3.0

Affiliation: Bayi Children's Hospital

Abstract

AimsTo investigate the association of several single nucleotide polymorphisms (SNPs) within vascular endothelial growth factor (VEGF) and vitamin D receptor (VDR) gene polymorphisms and additional gene- gene and gene- smoking interaction with multiple myeloma (MM) risk in Chinese population.MethodsGeneralized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking. Logistic regression was performed to investigate association between 6 SNPs within VEGF and VDR gene, additional gene- gene and gene- smoking interaction on MM risk.ResultsMM risk is significantly higher in carriers with the rs699947- A allele within VEGF gene than those with CC genotype (CA+ AA versus CC), adjusted OR (95%CI) =1.72 (1.19-2.33), and higher in carriers with rs2228570- T allele within VDR gene than those with CC genotype (CT+ TT versus CC), adjusted OR (95%CI) = 1.68 (1.26-2.17). We also found a significant two-locus model (p=0.0010) involving rs699947 and rs2228570, and a significant two-locus model (p=0.0107) involving rs2228570 andsmoking. Participants with rs699947- CA+AA and rs2228570- CT+TT genotype had the highest MM risk, compared to participants with rs699947- CC and rs2228570- CC genotype, OR (95%CI) = 3.12 (1.82 -4.61). Smokers with rs2228570- CT+TT genotype had the highest MM risk, compared to never- smokers with rs2228570- CC genotype, OR (95%CI) = 3.27 (1.74-4.86).ConclusionsWe found that the A allele of rs699947 within VEGF and T allele of rs2228570 within VDR gene, interaction between rs699947 and rs2228570, rs2228570 andsmoking were all associated with increased MM risk.

Highlights

Multiple myeloma (MM) is a fatal disorder of plasma cells derived from an early precursor of B-cell lineage and is responsible for about 2% of all cancer deaths [1]
MM risk is significantly higher in carriers with the rs699947- A allele within vascular endothelial growth factor (VEGF) gene than those with CC genotype (CA+ AA versus CC), adjusted OR (95%CI) =1.72 (1.19-2.33), and higher in carriers with rs2228570- T allele within vitamin D receptor (VDR) gene than those with CC genotype (CT+ TT versus CC), adjusted OR (95%CI) = 1.68 (1.26-2.17)
We found that the A allele of rs699947 within VEGF and T allele of rs2228570 within VDR gene, interaction between rs699947 and rs2228570, rs2228570 andsmoking were all associated with increased MM risk

Summary

Introduction

Multiple myeloma (MM) is a fatal disorder of plasma cells derived from an early precursor of B-cell lineage and is responsible for about 2% of all cancer deaths [1]. Recent studies indicated that BMI [3] and alcohol drinking [4] were associated with MM risk. Racial differences for MM incidence and familial clusters of the disease indicated that the role of genetic predisposition to MM should be taken seriously [2]. Some genes related to MM susceptibility have been reported in some studies, including vascular endothelial growth factor (VEGF) gene and vitamin D receptor (VDR) polymorphisms. Some polymorphisms within VEGF have been reported association with some types of cancer, such as rs699947, rs2010963 and rs833061 and so on [9,10,11]. The association between VEGF gene and MM risk were not well verified [12,13,14]

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