Abstract
BackgroundPolycystic ovarian syndrome (PCOS) is a multi-gene hereditary disorder caused by the interaction of certain gene variation with environmental factors. Previous studies have shown that vascular endothelial growth factor (VEGF) gene polymorphisms are associated with the risk of polycystic ovarian syndrome. However, the results of these studies remain controversial. We performed the present meta-analysis aiming to further investigate the potential relationship between VEGF polymorphisms and susceptibility to PCOS.MethodsThe following databases were systematically searched: PubMed, EMBASE, Web of Science (WOS), China National Knowledge Infrastructure (CNKI), and Wanfang Databases. The correlation between VEGF polymorphisms and PCOS risk was assessed by calculating pooled odds ratios (ORs) and their 95% confidence intervals (95% CIs). Subgroup analyses stratified by ethnicity and source of control were also conducted. Besides, trial sequential analysis (TSA) was done to verify the reliability of the pooled results.Results10 relevant case-control studies were incorporated in this meta-analysis, involving 1347 PCOS cases and 1378 controls. The VEGF rs2010963 polymorphism was associated with decreased PCOS risk in the whole population and the Asian populations. The VEGF rs3025039 polymorphism was associated with decreased PCOS susceptibility and the Asian populations, but increased risk of PCOS was observed among the Caucasian populations. In addition, the results of trial sequential analysis (TSA) showed the negative correlation between rs2010963 and PCOS risk, obtained by our meta-analysis, was stable and reliable.ConclusionOverall, different VEGF gene polymorphisms may exert different effects on PCOS susceptibility. The VEGF rs2010963 polymorphism decreases PCOS susceptibility in both the whole population and the Asian populations, and VEGF rs3025039 polymorphism causes lower PCOS susceptibility in the whole population and the Asian populations but higher in the Caucasian populations.
Highlights
Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases with complex etiology and pathogenesis, with a prevalence of up to 10% in reproductive age women [1, 2]
Literature search After formulating the search strategy, we systematically searched the databases of PubMed, EMBASE, Web of Science (WOS), Chinese National Knowledge Infrastructure (CNKI) and Wan Fang to collect potentially eligible case-control studies related to vascular endothelial growth factor (VEGF) gene polymorphisms and the risk of PCOS
Inclusion and exclusion criteria The studies included in this meta-analysis must meet the following criteria: (a) Case-control studies covered the relationship between VEGF gene polymorphisms and risk of PCOS. (b) The sample size, genotype distribution, and genotype frequency of the case and control groups were directly provided in the document, or the literature contained available original data that could be converted into Odds ratios (OR) value and 95%Confidence interval (CI) for the case and control groups. (c) The diagnosis of PCOS patients in the case group must conform to one of the following three diagnostic criteria: NIH, Rotterdam, and AE-PCOS Society [30–32] (d)
Summary
Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases with complex etiology and pathogenesis, with a prevalence of up to 10% in reproductive age women [1, 2]. It is generally characterized by high androgen, long-term persistent anovulation, and ovarian polycystic changes. PCOS is often associated with a variety of metabolic diseases involving patients with varying degrees of insulin resistance, hyperinsulinemia and hyperlipidemia [4]. It is generally believed that PCOS may be a multi-gene hereditary disorder caused by the interaction of certain genes with environmental factors. Polycystic ovarian syndrome (PCOS) is a multi-gene hereditary disorder caused by the interaction of certain gene variation with environmental factors.
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