Association of vascular endothelial growth factor gene polymorphism with psoriasis

Abstract

Background Psoriasis is an immune-mediated complex cutaneous disorder. In its pathologic process, there is abnormal keratinocyte differentiation and proliferation, as well as inflammation, besides abnormal vascular expansion. Vascular endothelial growth factor (VEGF) acts as a potent mediator of inflammation and angiogenesis in psoriasis. Objective This work aimed to study the role of VEGF gene polymorphism (rs2010963) in psoriasis vulgaris. Patients and methods This case–control study covered 45 patients with psoriasis vulgaris and 45 age-matched and sex-matched healthy participants as a control group, and had been checked to discover C-G transition polymorphism at position +405 of the VEGF gene by a real-time PCR. Results There was a significant difference between cases and controls concerning the distribution of VEGF gene polymorphism (P = 0.046), and also, there was a statistically significant difference between cases and controls concerning VEGF alleles (P = 0.036). Conclusion There was a significant association between the genotypes of the VEGF gene polymorphism and psoriasis vulgaris, suggesting that the VEGF gene polymorphism may have a possible active role in the etiopathogenesis of psoriasis vulgaris.