Abstract
Background Hyperuricemia has long been associated with increased cardiovascular risk, and arterial stiffness is proposed as a mediator. The present study is aimed at examining the associations of uric acid (UA) in blood and urine with arterial stiffness in a Chinese cohort. Methods A total of 2296 participants (mean age: 43.0 years) from our previously established cohort of Hanzhong Adolescent Hypertension Study were included. The participants were classified as subjects with or without arterial stiffness, which was defined as brachial-ankle pulse wave velocity (baPWV) ≥ 1400 cm/s and/or carotid intima-media thickness (CIMT) ≥ 0.9 mm. Multivariate regression analyses were used to examine the relationship between serum and urinary UA and the risk of arterial stiffness after adjusting for age, gender, systolic blood pressure, fasting glucose, BMI, heart rate, total cholesterol, and triglycerides. Results baPWV was positively correlated with urinary uric acid/creatinine ratio (uUA/Cre) (β = 0.061, P < 0.001), while CIMT was correlated with uUA/Cre (β = 0.085, P < 0.001) and fractional excretion of uric acid (FEUA) (β = 0.044, P = 0.033) in all subjects. In addition, uUA/Cre was significantly associated with the risk of high baPWV [1.032 (1.019-1.045)] and arterial stiffness [1.028 (1.016-1.040)]. Conclusion Our study showed that urinary UA excretion was significantly associated with the risk of arterial stiffness in Chinese adults. These findings suggest that UA, especially urinary UA, may be used as a simple, noninvasive marker for early detection of arterial stiffness in otherwise healthy subjects.
Highlights
Arterial stiffness is a strong predictor of cerebrovascular and cardiovascular diseases in patients with high risk and in the general population [1,2,3]
The prevalence of men, alcohol drinking, smoking, diabetes, and hypertension and age, SBP, DBP, total cholesterol, blood glucose, triglycerides, LDL, serum uric acid (SUA), serum creatinine, Brachial-ankle pulse wave velocity (baPWV), and Carotid intima-media thickness (CIMT) were higher in participants with arterial stiffness than in those without arterial stiffness, but HDL-C and fractional excretion of uric acid (FEUA) were higher in those without arterial stiffness
Associations of Serum and Urinary uric acid (UA) Levels with Arterial Stiffness. To extend this finding to clinical practice, we further investigated the association between UA and high baPWV or increased CIMT (CIMT ≥ 0:9 mm) based on multiple logistic regressions. urinary uric acid/creatinine ratio (uUA/Cre) was significantly associated with the risk of high baPWV [1.032 (1.019-1.045), P < 0:001] but not increased CIMT [1.546 (0.680-3.515), P = 0:299] after adjusting for confounding factors
Summary
Arterial stiffness is a strong predictor of cerebrovascular and cardiovascular diseases in patients with high risk and in the general population [1,2,3]. Brachial-ankle pulse wave velocity (baPWV), Disease Markers which reflects the function of the artery, is a classic artery elasticity measure and an independent predictor for cardiovascular events [4,5,6]. The participants were classified as subjects with or without arterial stiffness, which was defined as brachial-ankle pulse wave velocity ðbaPWVÞ ≥ 1400 cm/s and/or carotid intima-media thickness ðCIMTÞ ≥ 0:9 mm. Our study showed that urinary UA excretion was significantly associated with the risk of arterial stiffness in Chinese adults. These findings suggest that UA, especially urinary UA, may be used as a simple, noninvasive marker for early detection of arterial stiffness in otherwise healthy subjects
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
