Abstract
Many studies have been conducted to investigate the association between miR-27 rs895819 A > G and miR-423 rs6505162 C > A and cancer risk; however, the results are not consistent. In order to acquire a more precise assessment of the correlation, we performed this meta-analysis. We searched PubMed, EMBASE and Web of Science databases to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were applied to evaluate the correlation of these two microRNA polymorphisms with cancer risk. Forty-five eligible studies from thirty-five articles were included in our analysis. The results showed that rs895819 was associated with a decreased cancer risk in Caucasians (AG vs. AA: OR = 0.87, 95% CI = 0.79-0.96; GG+AG vs. AA: OR = 0.89, 95% CI = 0.81-0.98). When grouped by ethnicity, an increased risk was observed in colorectal cancer (G vs. A: OR = 1.19, 95% CI = 1.08-1.32; GG vs. AA: OR = 1.58, 95% CI = 1.28-1.96; GG vs. AG+AA: OR = 1.58, 95% CI = 1.29-1.93), while a decreased risk was found in breast cancer (G vs. A: OR = 0.93, 95% CI = 0.87-0.99; GG+AG vs. AA: OR = 0.91, 95% CI = 0.83-0.99). For rs6505162, a significantly decreased cancer risk was observed in lung cancer under all five genetic models. To summarize, our results indicated that rs895819 was a protective factor for cancer in Caucasians and could increase colorectal cancer risk but decrease breast cancer risk. Moreover, rs6505162 was a protective factor for lung cancer.
Highlights
In the current meta-analysis, a total of forty-five eligible case-control studies from thirty-five articles were included and their pooled results were used to assess the association of microRNA polymorphisms including miR-27 rs895819 and miR-423 rs6505162 with cancer susceptibility
We found that the rs895819 polymorphism www.impactjournals.com/oncotarget www.impactjournals.com/oncotarget lead to a reduction of individual susceptibility to cancer
We found that rs895819 could decrease the risk of breast cancer in allele contrast model and dominant model
Summary
A: the major allele; B: the minor allele; ASPCR: allele-specific PCR; GC: gastric cancer; CRC: colorectal cancer; LC: lung cancer; BC: breast cancer; GBC: gallbladder cancer; PC: prostate cancer; CC: cervical cancer; ESCC: esophageal squamous cell carcinoma; RCC: renal cell cancer; OC: ovarian cancer; HCC: hepatocellular carcinoma; PB: population based; HB: hospital based; a: Lithuania and Latvia; b: German, Lithuanian and Latvian; c: South Africa. For two common functional microRNA polymorphisms miR-27 rs895819 and miR-423 rs6505162, many case-control studies involving various cancer types have been performed among different ethnic populations, there is currently no consensus on whether there exists an association between these two microRNA polymorphisms and cancer risk because of inconsistent results published studies reported. We carried out an updated and systematic metaanalysis including those newly published articles to further assess the correlation of rs895819 and rs6505162 with cancer risk based on all available eligible studies at present. Of all the included studies, fifteen focused on breast cancer, eight on esophageal squamous cell carcinoma, six on gastric cancer, five on colorectal cancer, four on lung cancer, two on ovarian cancer, and one each on prostate cancer, gallbladder cancer, cervical cancer, renal cell cancer and hepatocellular carcinoma. A variety of genotyping methods including PCR-RFLP, MassARRAY, Taqman, Sequencing, PCR-LDR, SNaPshot, Allele-specific
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
