Association of triglycerides to high density lipoprotein cholesterol ratio with hypertension in Chinese adults: a cross-sectional study

Abstract

ABSTRACT Background It has been reported that there is a close correlation between triglycerides to high density lipoprotein cholesterol ratio (TG/HDL-C) and hypertension, but there are differences between different researches. The purpose of this study is to investigate the relationship between TG/HDL-C and hypertension in Chinese adults. Methods In this study, the open data for secondary analysis were obtained from DATADRYAD website (www.datadryad.org), and the raw data were from the Rich Healthcare Group Health. A total of 112 798 patients were enrolled in this study. The TG/HDL-C ratio was calculated as TG divided by HDL-C. Hypertension was defined as SBP ≥ 140 mmHg or DBP ≥ 90 mmHg. Logistic regression model was used to analyze the relationship between TG/HDL-C and hypertension. Sensitivity analysis and subgroup analysis were carried out to ensure the stability of the results. Results After adjusting for confounding factors, the increase of TG/HDL-C was independently associated with the risk of hypertension (HR, 95% CI; 1.11,1.07 ~ 1.16). Compared with the lowest quartile (Q1), the risk of hypertension increased with the increase of TG/HDL-C (Q2, Q3 and Q4) [HR, 95% CI; 1.17 (1.06–1.29); 1.25 (1.13–1.38); 1.37 (1.24–1.52)]. Moreover, the relationship between TG/HDL-C and hypertension was not linear, but showed the saturation effect, and the slope of the curve decreases with the increase of TG/HDL-C. Results of subgroup analysis showed that there was a significant correlation among BMI (>=18.5 kg/m2, <24 kg/m2) and females. Conclusion TG/HDL-C is positively associated with increased risk of hypertension in Chinese adults, especially women and normal BMI.