ASSOCIATION OF TRAUMATIC BRAIN INJURY AND HEART FAILURE: A PROPENSITY WEIGHTED ANALYSIS OF THE NATIONAL INPATIENT SAMPLE

Abstract

SESSION TITLE: Critical Care Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: The most common cause of death among trauma patients is traumatic brain injury (TBI). Although the exact cause of death is not well understood, it is thought to be a result of cerebral herniation. Associated catecholamine surge commonly precipitates heart failure (HF). We attempted to better characterize the correlation, if any, between TBI and HF. METHODS: A composite database of National Inpatient Sample (NIS) for 2016 and 2017 was queried using ICD-10 codes to identify patients with acute HF among a cohort of patients with TBI. A propensity weighted logistic regression analysis was performed controlling for age, gender, and comorbidities. Propensity weighted cohorts were compared for correlation with HF by age category. RESULTS: Among a cohort of 111,280 patients with traumatic brain injury, mean age was 58.3 +/- 0.15 years, of whom 39.61% were female. A propensity weighted logistic regression model was performed controlling for age, gender, and comorbidity (presence of AICD, Pacemaker, history of chronic heart failure, diabetes, ischemic stroke, COPD, PVD, CKD, OSA, hypertension, CAD). Acute diastolic HF was found to be associated with concussion [OR 1.549, 95% CI (1.002-2.394), p=0.049)]; Takotsubo cardiomyopathy was associated with diffuse TBI [OR 1.840, 95% CI (1.037-3.263), p=0.037)], traumatic cerebral edema in patients 40 years or older [OR 2.311, 95% CI (1.387-3.851), p=0.001)], and subarachnoid hemorrhage [OR 1.510, 95% CI (1.108-2.058), p=0.009)]. CONCLUSIONS: Patients with TBI should be monitored closely for HF development. CLINICAL IMPLICATIONS: Patients with TBI should be monitored closely for HF development. DISCLOSURES: No relevant relationships by Krishna Akella, source=Web Response No relevant relationships by Charles Arcoleo, source=Web Response No relevant relationships by Akella Chendrasekhar, source=Web Response No relevant relationships by Priscilla Chow, source=Web Response No relevant relationships by Kashif Hussain, source=Web Response No relevant relationships by Samer Ibrahim, source=Web Response No relevant relationships by Gunjan Joshi, source=Web Response No relevant relationships by Ghulam Mujtaba, source=Web Response No relevant relationships by Haaris Naji, source=Web Response No relevant relationships by Rajoo Patel, source=Web Response No relevant relationships by Heidi Roppelt, source=Web Response No relevant relationships by Nandini Seshan, source=Web Response No relevant relationships by Howard Sklarek, source=Web Response No relevant relationships by Liana Tatarian, source=Web Response No relevant relationships by Daisy Young, source=Web Response