Association of total testosterone status with bone mineral density in adults aged 40\u201360\xa0years

Nan Wang,Chengcheng Huang,Lixiang Wang

doi:10.1186/s13018-021-02714-w

Nan Wang, Chengcheng Huang + Show 1 more

Open Access

https://doi.org/10.1186/s13018-021-02714-w

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Abstract

ObjectiveEvidence linking total testosterone and bone mineral density (BMD) in adults is very limited. According to our review of the literature, only a few reports have focused on the relationship between total testosterone and bone mineral density in adults. Therefore, the purpose of this study was to determine the relationship between total testosterone and total bone mineral density in adults aged 40–60 years.MethodsWe used a cross-sectional study of a non-institutionalized U.S. population sample from the National Health and Nutrition Examination Survey. A weighted multivariate linear regression model was used to evaluate the relationship between total testosterone and total bone mineral density. Subgroup analyses were further performed.ResultsIn multiple regression models adjusted for potential confounders, total testosterone levels were inversely associated with total bone mineral density. However, in the sex-stratified subgroup analysis, the association between total testosterone levels and total bone mineral density was not significant in female adolescents. There was no negative association between total testosterone and total BMD among men, adults 40 to 60 years of age, and other racial/ethnic groups. There is a negative association between total testosterone and total bone mineral density when total testosterone concentration is greater than 500 ng/dL among Non-Hispanic black.ConclusionOur statistical results show that the association between total testosterone levels and total bone mineral density varies by gender and race. Elevated total testosterone levels below 500 ng/dL have adverse effects on bone health. Total testosterone concentrations below 500 ng/dL may have no effect on bone health.

Highlights

IntroductionStudies have shown that after menopause, women have lower estrogen levels, lower bone density, and develop osteoporosis
The traditional view is that male osteoporosis is similar to female osteoporosis, and sex hormone levels play an important role in regulating bone mass and metabolism
Study population The data analyzed came from the National Health and Nutrition Examination Survey (NHANES) (2011–2016), which is a stratified, multi-stage probability sample of the uninstitutionalized U.S population

Summary

Introduction

Studies have shown that after menopause, women have lower estrogen levels, lower bone density, and develop osteoporosis. Bone mineral density was positively correlated with estrogen levels in women. The relationship between male osteoporosis and hormone levels is often. The level of Testosterone in middleaged men gradually decreases, leading to the occurrence of Testosterone deficiency. The traditional view is that male osteoporosis is similar to female osteoporosis, and sex hormone levels play an important role in regulating bone mass and metabolism. Men with hypogonadism have faster bone metabolism, an increased risk of osteoporosis and brittle fractures. Men with osteoporosis have lower testosterone levels

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