Abstract
BackgroundToll-like receptor (TLR) single nucleotide polymorphisms (SNPs) have been associated with regulation of TLR expression and development of active tuberculosis (TB). The objectives of this study were to determine whether TLR8 and TLR9 SNPs were associated with the development of latent TB infection (LTBI) and the subsequent pulmonary TB (PTB) in a Chinese Han population.MethodsTwo independent samples were enrolled. The first sample contained 584 TB cases and 608 controls; the second sample included 204 healthy controls, 201 LTBI subjects and 209 bacteria-confirmed active PTB patients. Three SNPs (rs3764880, rs187084 and rs5743836) were genotyped. The associations between the SNPs and risk of LTBI or PTB were investigated using unconditional logistic regression analysis.ResultsThe A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37–0.91). The AA genotype of rs3764880 SNP was found to increase the risk of PTB among females with an OR of 4.81 (1.11–20.85). The G allele of TLR9 SNP rs187084 was found to increase the risk of PTB (G vs A, P = 0.01, OR = 1.48, 95% CI = 1.10–2.00), the significance was also observed under dominant genetic models. The GA-genotype of TLR9 rs187084 SNP was found to increase the risk of PTB with an OR of 1.68 (1.07–2.65), but was found to decrease the risk of MTB infection with an OR = 0.64 (0.41–0.98). TLR9_rs5743836 SNP was excluded from the data analyses, because the minimum allele frequency was< 1%.ConclusionsOur findings in two independent samples indicated that SNPs in TLR8 and TLR9 were associated with the development of TB, and highlight that SNPs may have different effects on disease pathogenesis and progression.
Highlights
Toll-like receptor (TLR) single nucleotide polymorphisms (SNPs) have been associated with regulation of Toll-like receptors (TLRs) expression and development of active tuberculosis (TB)
Wu L et al [32] reported that rs5743836 was a risk factor for latent TB infection (LTBI). These findings demonstrated that TLR8 and TLR9 play important roles in infectious diseases, and emphasized the role of the rs3764880 SNP in TLR8 and rs187084 and rs5743836 SNPs in TLR9
We investigated the associations of SNPs of TLR8 and TLR9 with TB in a Chinese Han sample
Summary
Toll-like receptor (TLR) single nucleotide polymorphisms (SNPs) have been associated with regulation of TLR expression and development of active tuberculosis (TB). The objectives of this study were to determine whether TLR8 and TLR9 SNPs were associated with the development of latent TB infection (LTBI) and the subsequent pulmonary TB (PTB) in a Chinese Han population. Most individuals exposed to MTB experience latent MTB infection (LTBI) and do not develop active disease. Toll-like receptors (TLRs) are a class of pattern recognition molecules, which are known to play important roles in the innate and adaptive immune system [6], by recognizing pathogen-associated molecular patterns. TLR7, TLR8, and TLR9 have been implicated in immune diseases due to their ability to recognize oligonucleotide-based (RNA-and DNA-based) molecular patterns as agonists [9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
