Abstract
The identification of dairy cows with higher milk yield potential has been pursued for many years in different herds. Genomic studies have suggested that Single Nucleotide Polymorphisms (SNPs) within major genes may affect milk production and consequently result economic benefit to the farmers. Toll-like receptor 4 (TLR4) is an immunogenic gene activating innate and adaptive immune responses which is present in very close proximity to the quantitative trait loci (QTL) affecting milk production traits. The present research work was designed to explore the possible genetic variations in 5′ upstream region of TLR4 gene in Vrindavani cattle and their possible associations with milk production traits viz. total lactation milk yield, 305days milk yield and lactation length. Nucleotide variability in 5′ upstream region of TLR4 gene was identified by PCR-RFLP and subsequent sequencing. The haplotypes were constructed using those SNPs. The association of these haplotypes with production traits was studied using SAS 9.3 software. Statistically significant association between these haplotypes and TLMY was observed. However, no significant association was found between haplotypes with MY305 and LL.
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