Abstract
Background Periodontitis is a kind of chronic infectious disease, affecting the health of billions of people. In recent years, a number of studies have shown that multiple immune gene polymorphisms are associated with the susceptibility to periodontitis, among which TLR-2 plays a critical role in periodontitis. But most of the studies reported TLR-2 gene polymorphism and susceptibility to periodontitis are not consistent. Therefore, we included all eligible studies in our study for further meta-analysis. Methods We used electronic databases, including CNKI, PubMed, EMBASE, and Web of Science databases, and relevant research published through June, 2020. Selecting studies involved case-control trials. For all eligibility studies, odds ratios (ORs) and 95% confidence intervals (95% CI) are provided or can be calculated from the study data. The size of the combined effect was calculated using STATA 15.0. Results Our meta-analysis included 14 articles representing 18 case-control studies with a total of 3873 cases and 3438 control subjects. Significant association was found between periodontitis and TLR-2 rs1898830 polymorphism under the allelic model (A allele vs. G allele: p = 0.014, OR = 1.208, 95% CI: 1.039-1.406), recessive model (GG vs. GA+AA: p = 0.028, OR = 0.755, 95% CI: 0.588-0.970), and codominant model (GG VS. AA: p = 0.014, OR = 0.681, 95% CI: 0.501-0.925). In subgroup analysis, TLR-2 rs5743708 polymorphism was associated with periodontitis risk in Asians under an allelic model (G allele vs. A allele: p = 0.017, OR = 12.064, 95% CI: 1.570-92.688), dominant model (GA+AA vs.GG: p = 0.016, OR = 0.08, 95% CI: 0.010-0.620), and codominant model (GA VS. GG: p = 0.016, OR = 1.026, 95% CI: 0.821-1.282). Conclusion The TLR-2 rs1898830, rs5743708 polymorphism may be associated with susceptibility to periodontitis. In the future, genome-wide approaches and large-scale, multiethnic case-control trials are still needed.
Highlights
Periodontitis is a chronic infectious disease caused by the accumulation of bacteria such as P.g (Porphyromonas gingivalis) and A.a (Aggregatibacter actinomycetemcomitans), which leads to the destruction of the surrounding periodontal tissue, including deep pockets, loss of attachment, and loss of the alveolar bone [1, 2]
A total of 6 gene polymorphism studies were included in this meta-analysis, and other single nucleotide polymorphism (SNP) of Toll-like receptors (TLRs)-2 such as rs7696323 and rs5743709 were reported only in one study
Exon 3 is the largest exon in TLR2 and contains several synonymous and nonsynonymous SNPS, as shown in the NCBI (NCBI build GRCh37).We identified four known SNPs: two common variants (rs574304, rs5743708 (Arg753Gln)) and two rare variants, a missense mutation in the third exon of the TLR2 gene, which has been the most internationally reported to be associated with periodontitis
Summary
Periodontitis is a chronic infectious disease caused by the accumulation of bacteria such as P.g (Porphyromonas gingivalis) and A.a (Aggregatibacter actinomycetemcomitans), which leads to the destruction of the surrounding periodontal tissue, including deep pockets, loss of attachment, and loss of the alveolar bone [1, 2]. A number of studies have shown that multiple immune gene polymorphisms are associated with the susceptibility to periodontitis, among which TLR-2 plays a critical role in periodontitis. TLR-2 rs5743708 polymorphism was associated with periodontitis risk in Asians under an allelic model (G allele vs A allele: p = 0:017, OR = 12:064, 95% CI: 1.570-92.688), dominant model (GA+AA vs.GG: p = 0:016, OR = 0:08, 95% CI: 0.010-0.620), and codominant model Genome-wide approaches and large-scale, multiethnic case-control trials are still needed
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