Abstract

<p> </p> <p><strong>Objective:</strong> We aim to determine the association of the time-of-day of bout-related moderate-to-vigorous physical activity (bMVPA) with changes in glycemic control across 4 years in adults with overweight/obese and type 2 diabetes. </p> <p><strong>Research Design and Methods: </strong>Among 2416 participants (57% female; mean age, 59 years) with 7-day waist-worn accelerometry recording at year 1 or 4, we assigned bMVPA timing groups based on the participants’ temporal distribution of bMVPA at year 1, and recategorized them at year 4. The time-varying exposure of bMVPA (≥10-minute bout) timing was defined as ≥50% of bMVPA occurring during the same time period (Morning, Midday, Afternoon, or Evening), <50% of bMVPA in any time period (Mixed), and ≤1 day with bMVPA per week (Inactive).</p> <p><strong>Results: </strong>HbA1c reduction at year 1 varied among bMVPA timing groups (P=0.02), independent of weekly bMVPA volume and intensity. The afternoon group had the greatest HbA1c reduction (<em>vs.</em> Inactive: -0.22% [95%CI -0.39%, -0.06%]), the magnitude of which was 30%-50% larger than the other groups. The odds of discontinuation versus maintaining or initiating glucose-lowering medications at year 1 differed by bMVPA timing (P=0.04). The afternoon group had the highest odds (OR: 2.13 [1.29, 3.52]). For all the year-4 bMVPA timing groups, there were no significant changes in HbA1c between year 1 and 4. </p> <p><strong>Conclusion: </strong>bMVPA performed in the afternoon is associated with improvements in glycemic control in adults with diabetes, especially within the initial 12 months of an intervention. Experimental studies are needed to examine causality.</p> <p> </p>

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.