Abstract
Considerable studies have been carried out to investigate the relationship between the polymorphisms of PPARG (Pro12Ala, C161T and C1431T) and serum lipid levels, but the results were inconclusive. Hence, we conducted a meta-analysis to clarify the association. MEDLINE, EMBASE and the Cochrane Library databases were searched systematically. The subgroup analysis was performed based on ethnicity. Seventy-four studies with 54,953 subjects were included in this meta-analysis. In Pro12Ala, the group with the ‘PP’ (C/C genotype) genotype group had lower levels of total cholesterol (TC) (mean difference, MD: −0.02, P < 0.00001; I2 = 28%), low-density lipoprotein cholesterol (LDL-C) (MD: −0.02, P < 0.00001; I2 = 30%) and higher levels of triglyceride (TG) (MD: 0.06, P < 0.00001; I2 = 30%) than the combined ‘PA+AA’ (PA = C/G genotype, AA = G/G genotype) genotype group in Asian population, and the group with the ‘PP’ genotype had higher levels of TG (MD: 0.07, P < 0.02; I2 = 67%) than the combined ‘PA+AA’ genotype group in non-Asian population. No statistically significant differences in the levels of TC, TG, high-density lipoprotein cholesterol, LDL-C were detected between different genotypes in C161T(Asian or non-Asian) and C1431T(Asian) polymorphisms. This meta-analysis was a renewed and confirmed study to assess the association between PPARG polymorphisms and serum lipid levels in Asian and non-Asian populations. There is a prominent association between Pro12Ala polymorphism and the levels of TC, LDL-C and TG in Asian population. No statistically significant differences in serum lipid levels were detected between different genotypes in C161T and C1431T polymorphisms.
Highlights
Cardiovascular disease (CVD), a global health-threatening problem, is a complex disease resulting from many risk factors, such as genetic factor [1, 2] and dyslipidaemia
The selection criteria for studies to be considered for this meta-analysis were as follows: (i) case–control studies published in peer-reviewed journals with full text available in English; (ii) studies on the relationship between PPARG Pro12Ala, C161T and C1431T polymorphisms and serum lipid levels; (iii) reporting at least one relevant outcomes of association between genotype and serum lipid levels
No statistically significant differences in the levels of total cholesterol (TC), TG, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) were detected between different genotypes in C161T (Asian or non-Asian) and C1431T (Asian) polymorphisms
Summary
Cardiovascular disease (CVD), a global health-threatening problem, is a complex disease resulting from many risk factors, such as genetic factor [1, 2] and dyslipidaemia. A large number of literatures have unravelled the correlation between genetic factors and dyslipidaemia [7,8,9,10] Among these reported genes, the genes that have been most widely studied are the peroxisome proliferator–activated receptor (PPAR) genes, which have three isotypes, namely a, c and d. Several single-nucleotide polymorphisms (SNPs) in the PPARG have been reported to be associated with dyslipidaemia and CVD These SNPs include Pro12Ala (rs1801282) [13, 16,17,18,19,20,21,22,23,24,25,26,27,28,29], C161T and C1431T (rs3856806) [15, 17, 30,31,32,33,34,35]
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