Abstract
BackgroundOur study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population.MethodsAll patients came from the east China area and underwent coronary angiography. Rs7025486 and rs1333049 polymorphism were genotyped in 555 patients with CAD and in 480 healthy controls that underwent coronary angiography.ResultsIn Chinese population, the rs7025486 genotype in the case group was no significant different than the control group (P = 0.531).Meanwhile, the rs1333049 SNP has statistically significant (P = 0.006), which was the independent risk factors for CAD (OR1.252, P = 0.039), and consistent with the past studies conclusion.ConclusionGenotype of rs1333049 on chromosome 9p21, but not rs7025486 on chromosome 9q33, is an independent determinant of the incidence of CAD in Chinese population.
Highlights
Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2 interacting protein (DAB2IP) and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population
The strongest association signal in the genome in Genomewide association studies (GWAS) studies for Coronary artery disease (CAD) and acute myocardial infarction (AMI) that has been published far comes from a number of singlenucleotide polymorphisms (SNPs) with a high degree of linkage disequilibrium between each individual on
A European GWAS reported that chromosome 9q33 contains a novel susceptibility locus DAB2IP associated with abdominal aortic aneurysm, early onset myocardial infarction, peripheral artery disease and pulmonary embolism [12]
Summary
Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population. Genomewide association studies (GWAS) have identified several genetic variants that increased susceptibility to CAD and acute myocardial infarction (AMI) in the primary prevention setting [3]. The strongest association signal in the genome in GWAS studies for CAD and AMI that has been published far comes from a number of singlenucleotide polymorphisms (SNPs) with a high degree of linkage disequilibrium between each individual on Recently, a European GWAS reported that chromosome 9q33 contains a novel susceptibility locus DAB2IP associated with abdominal aortic aneurysm, early onset myocardial infarction, peripheral artery disease and pulmonary embolism [12].
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