Abstract
Objective To further explore the association of the gene polymorphism in rs2294008 site of the prostate stem cell antigen (PSCA) with bladder cancer susceptibility. Methods The studies from databases for the association between PSCA rs2294008 polymorphisms and the susceptibility of bladder cancer were searched(published of paper from the computer retrieval to September 2016 ). For strict inclusion and exclusion criteria, extracted data, using NOS scale for quality evaluation. Then Meta-analysis was performed using Stata 12.0 software. The pooled OR with 95%CI were calculated to assess the association strength. Heterogeneity and publication bias were evaluated. Results A total of eight documents, including 13 case-control study involving 12 349 cases and 24 836 cases. The Meta-analysis showed: Analysis was stratified by ethnically and source of cases, allele frequency model (TvsC) [OR=1.15>1, 95%CI=1.12~1.19, P=0.000 1, 95% CI=1.20~1.33, P=0.000 1, 95% CI=1.08~1.21, P=0.000 T) polymorphism was significantly associated with bladder cancer. Conclusions PSCA rs2294008 (C>T) polymorphism and bladder cancer risk is significantly related and unrelated cases of ethnically and source, and mutant T allele may be bladder cancer susceptibility loci. PSCA is expected to be bladder cancer genetic susceptibility biomarkers. Key words: Urinary Bladder Neoplasms; Polymorphism, Genetic; Meta-Analysis
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