Abstract
Diabetes mellitus (DM) of a first degree relative is an important risk factor for developing type 2 diabetes mellitus (T2DM). The study investigated whether genetic polymorphism of the cytokine interleukine-1β (−511C/T) (IL-1B) was associated with the development of type 2 diabetes mellitus (T2DM) among first degree relative having diabetes mellitus (DM). Thirty five T2DM patients from north-eastern Thailand with a first degree relative with DM, 55 T2DM patients without a DM history of a first degree relative and 30 healthy controls were studied. Heterozygous individuals of IL-1B (CT) in the group of T2DM patients with a first degree relative with DM are significantly more frequent in comparison with the group of T2DM patients without a first degree relative with DM and with the controls. Genotypes between the T2DM patients without a DM relative and the controls were similar. The allele C did not differ between groups but the allele T significantly was more frequent for the T2DM patients with a relative with DM in comparison with the two other groups.
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