Association of the polymorphism in NUCB2 gene and the risk of type 2 diabetes

Chunyu Wang,Yulun Wang,Wenchao Hu

doi:10.1186/s13098-017-0235-z

Abstract

BackgroundNesfatin-1, originating from its precursor protein called nucleobindin 2 (NUCB2), plays an important role in glucose metabolism and diabetes. The aim of this study is to examine the association of the c.1012C>G (rs757081) polymorphism of NUCB2 gene with the presence of T2DM.MethodsThis study was performed in a population of 396 patients with T2DM and 196 healthy subjects. The c.1012C>G polymorphism of NUCB2 gene was determined using polymerase chain reaction and sequencing method.ResultsT2DM patients showed lower CG and GG genotype, as well as G allele frequencies compared with healthy subjects. Logistic regression analysis showed that c.1012C>G polymorphism was associated with a decreased risk of developing T2DM. In addition, GG genotype of NUCB2 was significantly correlated with lower levels of body mass index and fasting plasma glucose in patients with T2DM.ConclusionsThe c.1012C>G polymorphism of NUCB2 is associated with the decreased risk of developing T2DM in Chinese Han population.

Highlights

Nesfatin-1, originating from its precursor protein called nucleobindin 2 (NUCB2), plays an important role in glucose metabolism and diabetes
The association of c.1012C>G polymorphism with Type 2 diabetes mellitus (T2DM) As shown in Table 3, logistic regression analysis showed that c.1012C>G polymorphism was associated with a decreased risk of developing T2DM
After adjusting for age, gender, and Body mass index (BMI), c.1012C>G polymorphism was associated with a decreased risk of developing T2DM

Summary

Introduction

Nesfatin-1, originating from its precursor protein called nucleobindin 2 (NUCB2), plays an important role in glucose metabolism and diabetes. The aim of this study is to examine the association of the c.1012C>G (rs757081) polymorphism of NUCB2 gene with the presence of T2DM. Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by hyperglycemia. T2DM causes significant morbidity, disability, and early mortality, and imposes a huge economic burden on the individual, national healthcare, and economy [2]. Both genetic and environmental factors contribute to the incidence of T2DM. A number of genes and their polymorphisms have been shown to contribute to the pathogenesis of this disease [3]

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