Association of the mean platelet volume and red cell distribution width with dipper and non-dipper blood pressure in prehypertensive non-smokers

Mohammadreza Taban Sadeghi,Masoud Nouri-Vaskeh,Saeideh Aghayari Sheikh Neshin,Pantea Nazarpoori,Zahra Soroureddin

doi:10.1186/s13104-019-4868-x

Abstract

ObjectiveAbsence of nocturnal blood pressure (BP) dipping is associated with poor health outcomes, including increased mortality. Non-dipper BP seems to be a predictor of cardiovascular damage in hypertensive patients. The aim of this study was to investigate the association of the mean platelet volume (MPV) and red cell distribution width (RDW) with nocturnal dipping/non dipping status in newly diagnosed and untreated prehypertensive non-smokers, using ambulatory BP monitoring.ResultsTwenty-eight patients (15 males) in the dipper group and 24 patients (11 males) in the non-dipper group were evaluated in this study. The age of patients was 41.64 ± 15.01 and 37.96 ± 15.08 years in the dipper and non-dipper groups, respectively. The rate of nocturnal systolic BP drop in the dipper and non-dipper groups was 13.79 ± 3.35% (10.20–22.10) and 5.96 ± 2.87% (1.10–9.30) (P < 0.001), respectively. Also, the mean rate of nocturnal diastolic BP drop in the dipper and non-dipper groups was 17.02 ± 5.09% (10.30–26.90) and 6.19 ± 2.75% (1.20–9.70) (P < 0.001), respectively. RDW and MPV were significantly higher in non-dipper patients than dipper patients (P = 0.001 and P = 0.012, respectively). Bivariate analysis revealed that MPV was inversely correlated with the nocturnal systolic BP drop (P = 0.005, r = − 0.385). Furthermore, RDW was inversely correlated with systolic BP drop (P = 0.019, r = − 0.324).

Highlights

Cardiovascular diseases are the major cause of morbidity and mortality worldwide [1]
The findings showed that red cell distribution width (RDW) was inversely correlated with the SBP drop (P = 0.019, r = − 0.324)
Out findings revealed that dipping/non-dipping pattern in the circadian blood pressure (BP) course is associated with elevated RDW and mean platelet volume (MPV) in prehypertensive non-smoker patients

Summary

Results

The mean ± SD of nocturnal SBP drop in the dipper and non-dipper groups was 13.79 ± 3.35% (10.20–22.10) and 5.96 ± 2.87% (1.10–9.30) (P < 0.001), respectively. The mean rate of nocturnal DBP drop in dippers and non-dippers was 17.02 ± 5.09% (10.30–26.90) and 6.19 ± 2.75% (1.20–9.70) (P < 0.001), respectively. Independent t-test showed that MPV in the dipper group was significantly lower than that of the non-dipper group (P = 0.012) (Fig. 1). Independent t-test showed that RDW in the dipper group was significantly lower than that of the non-dipper group (P = 0.001) (Fig. 2). The bivariate analysis revealed that MPV was inversely correlated with nocturnal SBP drop (P = 0.005, r = − 0.385). The findings showed that RDW was inversely correlated with the SBP drop (P = 0.019, r = − 0.324).

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