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Abstract
Nestin, a member of the intermediate filament protein family, has been reported to be associated with several types of neoplastic transformation. However, questions remain, with studies reporting sometimes inconclusive or conflicting data. Thus, the aim of this study was to evaluate literature reports on the relationship between nestin and cancer stage. Relevant articles published as of June 2014 were retrieved from multiple databases. After applying specific inclusion criteria, we chose seven articles relating to nestin expression and cancer stage, which included a total of 223 positive/high nestin cases and 460 negative/low case-free controls. Overall, positive/high nestin was significantly associated with median or advanced stages of several types of cancer (nestin and cancer stage: OR = 1.90, 95% CI = 1.30-2.78; nestin and lymph node: OR = 2.17, 95% CI = 1.26-3.72). Notably, studies relating to lung cancer (three qualifying articles) showed a significant association between nestin and lung cancer stage (OR = 2.00, 95% CI = 1.16-3.44). These findings indicate that positive/high nestin may be more strongly linked to median or advanced cancer stage and correlated with malignant characteristics that lead to poor prognosis in different cancers, especially lung cancer.
Highlights
IntroductionA member of the class VI intermediate filament protein family, is expressed in normal cells of different tissues and organs.[3] Nestin expression was first reported in progenitor cells of central and peripheral nervous systems.[4] Its expression has since been reported in skeletal and cardiac muscle progenitors, developing tooth buds, testis and hair follicle sheath progenitor cells of the skin, a distribution that suggests that nestin is a www.impactjournals.com/oncotarget potential indicator of proliferative and multipotency status in several types of progenitor cells.[5, 6,7,8,9,10,11]
Nestin, a member of the class VI intermediate filament protein family, is expressed in normal cells of different tissues and organs.[3]
Recent reports have indicated that nestin might be linked to malignant characteristics, suggesting that abundant nestin expression correlates with greater malignancy and poorer prognosis in different cancers
Summary
A member of the class VI intermediate filament protein family, is expressed in normal cells of different tissues and organs.[3] Nestin expression was first reported in progenitor cells of central and peripheral nervous systems.[4] Its expression has since been reported in skeletal and cardiac muscle progenitors, developing tooth buds, testis and hair follicle sheath progenitor cells of the skin, a distribution that suggests that nestin is a www.impactjournals.com/oncotarget potential indicator of proliferative and multipotency status in several types of progenitor cells.[5, 6,7,8,9,10,11]. Recent reports have indicated that nestin might be linked to malignant characteristics, suggesting that abundant nestin expression correlates with greater malignancy and poorer prognosis in different cancers. A member of the intermediate filament protein family, has been reported to be associated with several types of neoplastic transformation. The aim of this study was to evaluate literature reports on the relationship between nestin and cancer stage
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