Association of the IL-17A rs2275913 and MIF rs755622 polymorphisms with the risk of gastric and colorectal cancer

Abstract

BackgroundInterleukin 17 (IL-17) and Macrophage migration inhibitory factor (MIF) are pro-inflammatory cytokines that play an important role in gastric and colorectal cancer pathogenesis. AimThe main objective of our study is to investigate the potential association of IL-17A (−197G > A) rs2275913 and MIF (−173 G > C) rs755622 polymorphisms with susceptibility to gastric and colorectal cancers in Moroccan population. MethodsWe conducted a case-control study that included 70 gastric cancer patients; 70 colorectal cancer patients; and 70 healthy controls. Genotyping was performed with real-time polymerase chain reaction (PCR), using a TaqMan single-nucleotide polymorphism (SNP) genotyping assay. ResultsThe mutant genotype AA of the IL-17 rs2275913 polymorphism was correlated with a higher risk of developing colorectal cancer than the GG and AG genotypes combined [odds ratio (OR) = 2.7284; 95% confidence interval (CI) = 1.6491–4.5141, p = .0001]. The wild type genotype GG of the MIF rs755622 polymorphism has a slight protective effect against colorectal [odds ratio (OR) = 0.1262; 95% confidence interval (CI) = 0.0148–1.0733, p = .0581] and gastric cancer [odds ratio (OR) = 0.0749; 95% confidence interval (CI) = 0.0090–0.6237, p = .0165]. ConclusionThe IL-17A rs2275913 (−197G > A) polymorphism could contribute to the risk of colorectal cancer and may be utilized as a genetic screening marker in assessing colorectal cancer risk in the Moroccan population.