Association of the IL-4R Q576R Polymorphism with Pediatric Asthma: a meta-analysis.

Abstract

The relationship between Q576R polymorphism of IL-4 receptor (IL-4R) gene and pediatric asthma risk is still undefined. To this end, this meta-analysis was performed to explore the above controversy. In this study, we systemically retrieved CNKI, EMBASE, Web of Science, Scopus, Science direct and Pub Med to collect relevant researches, followed by calculation of odds ratio (OR) along with 95% confidence intervals (CIs). STATA 12.0 software was employed in this meta-analysis. We found an association between IL-4R Q576R polymorphism and pediatric asthma risk (GG vs AA: OR = 3.75, 95% CI = 1.89-7.45; AG vs AA: OR = 2.15, 95% CI = 1.36-3.39; the dominant model: OR = 2.25, 95% CI = 1.42-3.57;the recessive model: OR = 3.05, 95% CI = 1.54-6.05). Moreover, there was no obvious publication bias. Our findings suggested that G allele of IL-4R Q576R polymorphism is associated with increased risk of pediatric asthma. Anyhow, delicately-designed, large-scale studies should be conducted to further confirm the current outcomes.