Abstract
To investigate the association of the gene polymorphism of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4)with Graves′ ophthalmopathy(GO)in Qinghai Tibetans. 130 case of Graves′ disease(GD)were selected from June 2013 to November 2016 in The People′s Hospital of Qinghai Province. These patients were assigned into 2 groups, GO(n=71)and GD without GO(n=59). The genotypes and alleles of CTLA-4 gene were detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Distribution of CTLA-4 exon 1(+ 49A/G)genotype frequencies(AA, AG, and GG)was different between 2 groups. (Chin J Endocrinol Metab, 2017, 33: 962-964) Key words: Graves′ disease; Polymorphism, restriction fragment length
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