Abstract
Fasting triglyceride concentrations and insulin resistance vary substantially according to patient ethnic origin(1)(2), but the role of genetic variants in these differences is not known. The fatty acid binding protein 2, intestinal ( FABP2 ) gene encodes the intestinal fatty acid binding protein, which is involved in intestinal fatty acid uptake. Carriers of the T54 variant (c.163G>A;p.A54T) of FABP2 produce a modified, functional intestinal fatty acid binding protein that has high affinity for fatty acids. Thus carriers have higher triglyceride concentrations and insulin resistance than noncarriers(3). However, many of the studies in which this association was observed did not account for variations in health behaviors (e.g., physical activity and diet) and adiposity, which may also affect triglyceride concentrations and insulin resistance. Also, among individuals who consume a high-fat diet, T54 carriers may have higher lipids than noncarriers(4). We investigated the association of the FABP2 T54 variant with fasting triglyceride concentrations and insulin resistance in a multiethnic population, and by controlling for ethnicity, health behaviors, and adiposity we specifically focused on the explanatory power of this genetic variable. We also tested for interactions of the T54 variant with dietary variables. Study participants were selected by stratified random sampling from 3 urban centers in Canada. The study population included a total of 972 persons of 3 ethnic origins, South Asian (n = 337), Chinese (n = 313), and European (n = 322).1 The mean (SD) age of this population was 49.6 (9.9) years; 51.5% were women (n = 501); 9.8% (n = 95) had confirmed type 2 diabetes; and 5.6% (n = 54) reported having had a cardiovascular disease episode (heart attack, stroke, or angina). Participants completed questionnaires on medical history, tobacco use, alcohol intake, physical activity, and diet. Study participants underwent an oral glucose tolerance …
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
