Association of the coexistence of intracranial atherosclerotic disease and cerebral small vessel disease with acute ischemic stroke

Abstract

PurposeWhether the coexistence of intracranial atherosclerotic disease (ICAD) and cerebral small vessel disease (CSVD) is an effective indicator for acute ischemic stroke (AIS) is unclear. This study aimed to investigate the association of coexistence of ICAD and CSVD with AIS. MethodsPatients with symptomatic ICAD were recruited from a multicenter study. All patients underwent intracranial artery vessel wall and brain magnetic resonance (MR) imaging at 3.0 T. The characteristics of T1 hyperintensity, plaque enhancement, and surface irregularity of the ICAD were assessed. The types of CSVD including enlarged perivascular space, white matter hyperintensity and lacune, and AIS were also analyzed. Logistic regressions were used to evaluate the associations of coexistence of ICAD and CSVD with AIS. ResultsOf 122 recruited patients (mean age: 56.69 ± 11.07 years; 70 males), 69 (56.56%) had AIS. Coexistence of ICAD and CSVD was more likely found in patients with AIS compared to those without AIS (all P < 0.05). After full adjustment, coexistences of surface irregularity and EPVS (odds ratio [OR], 12.770; 95% confidence interval [CI], 2.163–75.380; P = 0.005), surface irregularity and lacune (OR, 8.450; 95% CI, 2.028–35.213; P = 0.003), enhancement and lacune (OR, 13.888; 95% CI, 2.888–66.786; P = 0.001), surface irregularity and WMH (OR, 3.692; 95% CI, 1.264–10.786; P = 0.017), and enhancement and WMH (OR, 7.899; 95% CI, 2.357–26.475; P = 0.001) were significantly associated with AIS. ConclusionCoexistence of intracranial atherosclerosis and cerebral small vessel disease might be a stronger indicator for acute ischemic stroke than each alone.