Association of the Child Opportunity Index and Inpatient Illness Severity in the United States, 2018-2019

Abstract

ObjectiveChildren residing in impoverished neighborhoods have reduced access to healthcare resources. Our objective was to identify potential associations between Child Opportunity Index (COI), a composite score of neighborhood characteristics, and inpatient severity of illness and clinical trajectory among United States (US) children. MethodsThis retrospective cohort study assessed data using the Pediatric Health Information System Registry from 2018 and 2019. Primary exposure variable was COI level (range: very low [CO1 1], low [COI 2], moderate [COI 3], high [COI 4], and very high [COI 5]). Markers of inpatient clinical severity included index mortality, Pediatric Intensive Care Unit (PICU) admission, invasive mechanical ventilation (IMV), and hospital length of stay (LOS). Subgroup analysis of COI variance and clinical outcome variation by United States Census Geographic Regions was conducted. Adjusted regression analysis was utilized to understand associations between COI and inpatient clinical severity outcomes. ResultsOf the 132,130 encounters, 44% resided in very low or low COI neighborhoods. In adjusted models, very low COI was associated with increased mortality (aOR: 1.35, 95% CI: 1.05-1.74, P = 0.002), PICU admission (aOR: 1.06, 95% CI: 1.02-1.11, P = 0.014), IMV (aOR: 1.12, 95% CI: 1.04-1.21, P = 0.002), and higher hospital LOS (P = 0.045). Regional variation by COI depicted the East North Central region having the highest rate of mortality (20.5%), p < 0.001, and PICU admissions (23%), p = 0.014. ConclusionOur multicenter, retrospective study highlights the interaction between neighborhood-level deprivation and worsened health disparities, indicating a need for prospective study. What’s NewOur study adds a national assessment of hospitalized children and their clinical outcomes as it relates to the Childhood Opportunity Index. We indicate areas that public health research and intervention should focus to determine approaches for more equitable healthcare.