Abstract
IntroductionCurrently, there is limited information about the relationship between manganese superoxide dismutase (sod2) c47t polymorphism and susceptibility to noise-induced hearing loss (NIHL). ObjectiveThe aim of this meta-analysis was to clarify the association between SOD2 C47T polymorphism and NIHL. MethodsA search in PubMed and Web of Science was performed to collect data. All full-text, English-written studies containing sufficient and complete case-and-control data about the relationship between SOD2 C47T polymorphism and NIHL were included. Three eligible studies, comprising 1094 subjects, were identified. pooled odds ratios (ORs) and 95% confidence intervals (CI) were calculated to evaluate the strength of the association between SOD2 C47T polymorphism and NIHL. ResultsNo significant association between C47T polymorphism and risk of NIHL was found with the following combinations: T vs. C (OR=0.83; 95% CI=0.63–1.09); TT vs. CC (OR=0.49; 95% CI=0.22–1.09); CT vs. CC (OR=0.54; 95% CI=0.25–1.17); TT vs. CC+CT (OR=0.82; 95% CI=0.50–1.32); CC vs. TT+TC (OR=0.49; 95% CI=0.23–1.04). However, in subgroup analysis, a significant association was found for TT vs. CC+CT (OR=0.77; 95% CI=0.42–1.41) in the Chinese population. ConclusionThe present meta-analysis suggests that SOD2 C47T polymorphism is significantly associated with increased risk of NIHL in the Chinese population. Further large and well-designed studies are needed to confirm this association.
Highlights
There is limited information about the relationship between manganese superoxide dismutase c47t polymorphism and susceptibility to noise-induced hearing loss (NIHL)
Fortunato et al.[6] previously showed that SOD2 polymorphisms could predispose to NIHL by exerting variable local tissue antioxidant roles, whereas Wang et al.[14] only showed a weak association between SOD2 polymorphisms and NIHL
In this study, a meta-analysis with a relatively large sample was conducted in order to generate a more reliable conclusion regarding the relationship between SOD2 C47T polymorphism and NIHL
Summary
There is limited information about the relationship between manganese superoxide dismutase (sod2) c47t polymorphism and susceptibility to noise-induced hearing loss (NIHL). English-written studies containing sufficient and complete case-and-control data about the relationship between SOD2 C47T polymorphism and NIHL were included. Genes involved in the regulation of releasing of free radicals were examined,[5] and manganese superoxide dismutase (SOD2) was identified.[6]. SOD2 is a homotetramer located within the mitochondrion and is an enzyme involved in the conversion of superoxide radicals to hydrogen peroxide.[7] Among the polymorphisms identified in the SOD2 gene, C47T is the most widely studied. In this study, a meta-analysis with a relatively large sample was conducted in order to generate a more reliable conclusion regarding the relationship between SOD2 C47T polymorphism and NIHL
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