Abstract
Polymorphisms in DNA repair genes may alter DNA repair capacity and, consequently, lead to genetic instability and carcinogenesis. Several studies have investigated the association of the Asp312Asn and Lys751Gln polymorphisms in the xeroderma pigmentosum complementation group D (XPD) gene with the risk of non-Hodgkin’s lymphoma (NHL), but the conclusions have been inconsistent. Therefore, we performed this meta-analysis to more precisely estimate these relationships. A systematic literature search was performed using the PubMed, Embase, and Chinese Biomedical (CBM) databases. Ultimately, 6 studies of Asp312Asn, comprising 3,095 cases and 3,306 controls, and 7 studies of Lys751Gln, consisting of 3,249 cases and 3,676 controls, were included. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of each association. Overall, no association was observed between the Asp312Asn polymorphism and NHL risk (homozygous: OR = 1.11, 95% CI = 0.94-1.32; heterozygous: OR = 1.00, 95% CI = 0.89-1.11; recessive: OR = 1.12, 95% CI = 0.95-1.31; dominant: OR = 1.02, 95% CI = 0.92-1.13; and allele comparison: OR = 1.04, 95% CI = 0.96-1.12) or between the Lys751Gln polymorphism and NHL risk (homozygous: OR = 0.97, 95% CI = 0.83-1.15; heterozygous: OR = 0.96, 95% CI = 0.86-1.06; recessive: OR = 1.00, 95% CI = 0.86-1.16; dominant: OR = 0.96, 95% CI = 0.87-1.06; and allele comparison: OR = 0.98, 95% CI = 0.91-1.05). Furthermore, subgroup analyses did not reveal any association between these polymorphisms and ethnicity, the source of the controls, or the NHL subtype. These results indicated that neither the Asp312Asn nor Lys751Gln XPD polymorphism was related to NHL risk. Large and well-designed prospective studies are required to confirm this finding.
Highlights
Non-Hodgkin’s lymphoma (NHL) represents a large heterogeneous group of B-cell and T-cell lymphomas characterized by uncontrolled malignant clonal expansion
80%-90% of all NHLs originate from B cells, i.e., B-cell lymphomas, which are further categorized into two major subtypes: diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) [1]
Three studies were conducted on Caucasians, 1 on Asians, and 2 on mixed ethnicities for the Asp312Asn polymorphism; 3 were conducted on Caucasians, 2 on Asians, and 2 on mixed ethnicities for the Lys751Gln polymorphism
Summary
Non-Hodgkin’s lymphoma (NHL) represents a large heterogeneous group of B-cell and T-cell lymphomas characterized by uncontrolled malignant clonal expansion. 80%-90% of all NHLs originate from B cells, i.e., B-cell lymphomas, which are further categorized into two major subtypes: diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) [1]. The incidence of NHL continues to increase worldwide, and an estimated 355,900 new NHL cases and 191,400 NHL deaths occurred in 2008 [2]. NHL imposes a heavy burden on patients by reducing quality of life and work ability and by increasing disability. The etiology of NHL has yet to be fully understood. It is well known that single nucleotide polymorphisms (SNPs), common sources of human genetic variation, may contribute to an individual’s susceptibility to cancer, including NHL [3,4,5]
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