Abstract
BackgroundAlthough several researches have reported the connection between the transforming growth factor-beta 1 (TGF-β1) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent. Here, this paper proposed a meta-analysis to evaluate whether the TGF-ß1 gene polymorphisms, −509C/T (rs1800469), codon 10 T/C (rs1982073) and codon 25G/C (rs1800471), were associated with chronic HCV infection.MethodsThe summary odds ratios (ORs) of chronic HCV infected patients and controls with all SNPs were obtained by adaptive fixed or random effect model. A series of statistical tools were employed to guarantee the accuracy of related pooling ORs, including the Hardy-Weinberg equilibrium (HWE) test, sensitivity analysis and publication bias test.ResultsThis paper analyzed 18 case-control studies in 17 articles which totally contains 2718 chronic HCV infection cases corresponding to 1964 controls. The results of the meta-analysis indicated that the −509C/T polymorphism effected an increased risk of chronic HCV infection in all gene models. More specifically by ethnicity stratification, the Egyptians shared the similar association with the above overall study. Moreover, the meta-fusion of healthy control studies showed that − 509 T allele carriers (TT + TA) had nearly 2.00 and 3.36 fold higher risk of chronic HCV infection in the total and Egyptian populations, respectively (OR = 2.004, 95% CI = 1.138–3.528, P = 0.016; OR = 3.363, 95% CI = 1.477–7.655, P = 0.004, respectively). However, our meta-analysis did not find any significant association between the codon 10 T/C or codon 25G/C polymorphisms and chronic HCV infection.ConclusionsOur results suggested that the TGF-ß1–509C/T polymorphism may effect an increased risk of chronic HCV infection, especially in Egyptian population.
Highlights
Several researches have reported the connection between the transforming growth factorbeta 1 (TGF-β1) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent
One out of three chronic hepatitis C (CHC) patients will progress to hepatic complications such as hepatic fibrosis, liver cirrhosis (LC), eventually hepatocellular carcinoma (HCC), which leads to high mortality [2]
We proposed a meta-analysis by pooling the small size case-control results statistically to further clarify the role of TGF-ß1–509C/T, codon 10 T/C, and codon 25G/C polymorphisms in chronic HCV infection in order to overcome the drawbacks of unbalance sampling data-driven experiment result
Summary
Several researches have reported the connection between the transforming growth factorbeta 1 (TGF-β1) gene polymorphisms and chronic hepatitis C virus (HCV) infection, the conclusions of these studies were not always consistent. This paper proposed a meta-analysis to evaluate whether the TGF-ß1 gene polymorphisms, −509C/T (rs1800469), codon 10 T/C (rs1982073) and codon 25G/C (rs1800471), were associated with chronic HCV infection. Hepatitis C virus (HCV) infection which is a widely prevalent infectious disease has presented in about 170 million people of the world [1]. There are 60–80% of patients with the acute infection developing into chronic hepatitis C (CHC). The −509C/T (rs1800469), codon 25G/C (rs1800471), and codon 10 T/C (rs1982073) SNPs are the most widely evaluated polymorphisms [10, 11]. The above facts suggest that −509C/T, codon 25G/C, and codon 10 T/C SNPs may contribute to TGF-β1-mediated immune response in HCV infection
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